The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
In Vitro Anti-Propionibacterium Activity by Curcumin Containing Vesicle System
Open accessAbstract
Propionibacterium acnes acts a critical role in the development of inflammatory acne when it overgrows in pilosebaceous units. The spread of multiple drug resistance bacteria indicates a growing need for new antimicrobial agents. The objective of this study is to develop lipid vehicles to deliver curcumin and inhibit P. acnes in the skin. The inhibitory activities of the curcumin containing vehicles against P. acnes were studied by the bioluminescence assay. Curcumin accumulation patterns in neonate pig skin were studied using Franz diffusion cells and confocal laser scanning microscopy. The physicochemical properties of the curcumin containing vehicles including interfacial tension, size distribution and viscosity were analyzed. Significant curcumin accumulation (362±8 µg/g skin) was observed with the lipid vehicles developed herein. Curcumin (0.43 µg/mL) in the vehicles significantly inhibited the growth of P. acnes. Confocal laser scanning microscopy confirmed the formation of curcumin reservoir in the skin by the curcumin-loaded vehicles. Curcumin-loaded vehicles could efficiently accumulate in the skin and inhibit P. acnes in vitro. Our results highlight the potential of using vehicles containing lauric acid and curcumin as an alternative treatment for acne vulgaris.
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“This is based on the ability of lauric acid and curcumin niosomes to enhanced antibacterial activity of products against skin infections [87].”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [87]
In the citing paper
“However, lauric acid liposomes at the nanoscale have shown enhanced antibacterial efficacy against acne.”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [87]
Citations
Cites
Microemulsions as carriers for drugs and nutraceuticals
Spernath, A., & Aserin, A. (2006) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2006.11.016 · Cited by 329
Garti, N., Yaghmur, A., Leser, M. E., Clement, V., & Watzke, H. J. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf001390b · Cited by 241
The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes
Yang, D., Pornpattananangkul, D., Nakatsuji, T., Chan, M., Carson, D. A., Huang, C., & Zhang, L. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.033 · Cited by 218
Terpene microemulsions for transdermal curcumin delivery: Effects of terpenes and cosurfactants
Liu, C., Chang, F.-Y., & Hung, D.-K. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2010.08.018 · Cited by 150
Self-citationAkhter, S., Jain, G. K., Ahmad, F. J., Khar, R. K., Jain, N., Khan, Z. I., & Talegaonkar, S. (2008) · Current Nanoscience · doi:10.2174/157341308786306071 · Cited by 73
Agrawal, V., Gupta, V., Ramteke, S., & Trivedi, P. (2010) · AAPS PharmSciTech · doi:10.1208/s12249-010-9540-7 · Cited by 58
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Metadata
- Authors
- Liu, C.-H., & Huang, H.-Y.
- Affiliations
- Chang Gung University (TW)
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2013
- Volume
- 61
- Issue
- 4
- Pages
- 419-425
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W2068145965
- Cited by
- 52
- References
- 6
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 7 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 1 · 2014: 1
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Chemical and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Chang Gung Medical Foundation
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Keywords
- curcumin, Propionibacterium acnes, acne, lipid vesicles, antimicrobial activity, lauric acid, skin penetration, bioluminescence assay, confocal laser scanning microscopy, Franz diffusion cell
- MeSH terms
- Acne Vulgaris, Animals, Anti-Bacterial Agents, Curcumin, Humans, Lauric Acids, Liposomes, Particle Size, Propionibacterium acnes, Skin, Skin Absorption, Surface Tension, Swine, Viscosity
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