Cited by 168Cardiovascular and exercise physiologySports Performance and TrainingHypothalamic control of reproductive hormones

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Effects of menstrual phase and amenorrhea on exercise performance in runners

DE SOUZA, MARY JANE, MAGUIRE, MOLLY S., RUBIN, KAREN R., MARESH, CARL M.·1990·Medicine & Science in Sports & Exercise

DOI 10.1249/00005768-199010000-00006

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Abstract

There are few well controlled studies in terms of subject selection, menstrual classification, and exercise protocol that have examined both maximal and submaximal exercise responses during different phases of the menstrual cycle in eumenorrheic runners and compared these runners to amenorrheic runners. Thus, the purpose of this study was to measure selected physiological and metabolic responses to maximal and submaximal exercise during two phases of the menstrual cycle in eumenorrheic runners and amenorrheic runners. Eight eumenorrheic runners (29.0 +/- 4.2 yr) and eight amenorrheic runners (24.5 +/- 5.7 yr) matched for physical, gynecological, and training characteristics were studied. The eumenorrheic runners performed one maximal and one submaximal (40 min at 80% VO2max) treadmill run during both the early follicular (days 2-4) and midluteal (6-8 d from LH surge) phases. The amenorrheic runners performed one maximal and one submaximal (40 min at 80% VO2max) treadmill run. Cycle phases were documented by urinary luteinizing hormone and progesterone assays and by plasma estradiol and progesterone assays. No differences were observed in oxygen uptake, minute ventilation, heart rate, respiratory exchange ratio, rating of perceived exertion, time to fatigue (maximal), and plasma lactate (following the maximal and submaximal exercise tests) between the follicular and luteal phases in the eumenorrheic runners and the amenorrheic runners. We conclude that neither menstrual phase (follicular vs luteal) nor menstrual status (eumenorrheic vs amenorrheic) alters or limits exercise performance in female athletes.

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Items 101–167 of 167

EFFECT OF THE MENSTRUAL CYCLE PHASE AND DIET ON BLOOD LACTATE RESPONSES TO EXERCISE.
Berend, J. Z., Brammeier, M. R., Jones, N., Holliman, S. C., & Hackney, A. C. (1994) · PubMed · Cited by 10
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Oral Contraceptive Use and Physical Performance
VanHeest, J. L., Mahoney, C. E., & Rodgers, C. D. (2005) · doi:10.1002/9780470757826.ch19 · Cited by 9
Female athletes: Factors impacting successful performance
VanHeest, J. L., & Mahoney, C. E. (2007) · Current Sports Medicine Reports · doi:10.1007/s11932-007-0027-6 · Cited by 8
Effect of Menstrual Phase on the Acetate Correction Factor Used in Metabolic Tracer Studies
Oosthuyse, T., Bosch, A. N., & Jackson, S. (2003) · Canadian Journal of Applied Physiology · doi:10.1139/h03-061 · Cited by 8
“Moreover, whole body substrate utilisation based on RER may vary according to menstrual phase (Dombovy et al., 1987; Hackney et al., 1991; Zderic et al., 2001), although these findings are not consistently observed (De Souza et al., 1990; Kanaley et al., 1992).”
BackgroundResult
Trends and Missing Links in (De)Hydration Research: A Narrative Review
Rebelo‐Marques, A., Coelho-Ribeiro, B., Lages, A. D. S., Andrade, R., Afonso, J. R., Pereira, R., Batista, A. S., Teixeira, V. H., & Jácome, C. I. O. (2024) · Nutrients · doi:10.3390/nu16111709 · Cited by 9
Influence of Menstrual Cycle on Maximal Aerobic Power of Young Female Adults
Lamina, S., Hanif, S., & Muhammed, H. (2011) · African Journal of Physiotherapy and Rehabilitation Sciences · doi:10.4314/ajprs.v3i1.7 · Cited by 7
Monitoring Menstrual Health in Footballers: Considerations for Tracking Menstrual and Hormonal Contraceptive Cycles in the Field to Support Performance
Mikkonen, R. S., Ihalainen, J. K., Bruinvels, G., Mkumbuzi, N. S., Smith‐Ryan, A. E., Kaikkonen, M., Kasongo, M., & Hackney, A. C. (2025) · Sports Medicine · doi:10.1007/s40279-025-02338-8 · Cited by 7
Does the Menstrual Cycle Impact the Maximal Neuromuscular Capacities of Women? An Analysis Before and After a Graded Treadmill Test to Exhaustion
Morenas‐Aguilar, M. D., Ruiz‐Alias, S. A., Blanco, A. M., Lago‐Fuentes, C., García‐Pinillos, F., & Pérez‐Castilla, A. (2023) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000004542 · Cited by 6
Changes in Concentration of Creatine Kinase, Body Composition and Lipoprotein during Menstrual Cycle
Daniusevičiūtė, L., Brazaitis, M., Skurvydas, A., Sipavičienė, S., Linonis, V., Piečaitienė, J., & Eimantas, N. (2018) · Baltic Journal of Sport and Health Sciences · doi:10.33607/bjshs.v2i77.374 · Cited by 6
“Most studies found no significant change in bodyweight over the menstrual cycle (Horvath et al., 1982; De Souza et al., 1990; Stachenfeld et al., 2000).”
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Effects of Female Reproductive Hormones on Sports Performance
Lebrun, C. M., Joyce, S., & Constantini, N. (2020) · Contemporary Endocrinology · doi:10.1007/978-3-030-33376-8_16 · Cited by 7
An Overarching Conceptual Framework for Menstrual Health in Sport Research: Theory, Causality and Validation
Oester, C., Norris, D., Lovell, R. J., Pedlar, C. R., Bruinvels, G., & Kalkhoven, J. T. (2026) · Sports Medicine · doi:10.1007/s40279-026-02411-w · Cited by 6
Ventilation differences in the menstrual cycle: A systematic review and meta-analysis
Rattley, C. A., Ansdell, P., Burgess, L. C., Felton, M., Dewhurst, S., Armstrong, M., & Neal, R. A. (2025) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2025.104468 · Cited by 5
Influence of menstrual cycle phase and oral contraceptive phase on exercise performance in endurance-trained females
Oxfeldt, M., FREDERIKSEN, L. K., GUNNARSON, T., & Hansen, M. (2024) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.23.15458-2 · Cited by 5
Influence of menstrual phase on ventilatory response to submaximal exercise
Oosthuiyse, T., & Bosch, A. (2006) · South African Journal of Sports Medicine · doi:10.17159/2078-516x/2006/v18i2a241 · Cited by 5
Sex Hormones and Their Impact on the Ventilatory Responses to Exercise and the Environment
Duke, J. W. (2016) · Springer eBooks · doi:10.1007/978-3-319-44558-8_2 · Cited by 5
Knowledge and attitudes regarding the menstrual cycle, oral contraceptives, and sport performance : the conceptualization and development of a questionnaire for athletic coaches
Johnson, T. R. (2008) · Cited by 5
Effect of Menstrual Cycle Phase on Perceived Exertion During Aerobic Exercise in Eumenorrheic Women: A Systematic Review and Meta-analysis.
Prado, R. C. R., Hackney, A. C., Silveira, R., Kilpatrick, M. W., Takito, M. Y., & Asano, R. Y. (2024) · PubMed · Cited by 4
Menstrual phase does not influence ventilatory responses to group III/IV afferent signaling in eumenorrheic young females
Lee, E., Vera, K., Asirvatham‐Jeyaraj, N., et al. (2021) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2021.103712 · Cited by 4
Effects of regular aerobic exercise on post-exercise vagal reactivation in young female
Nakamura, M., Hayashi, K., Aizawa, K., Mesaki, N., & Kono, I. (2013) · European Journal of Sport Science · doi:10.1080/17461391.2013.774054 · Cited by 4
Neuromuscular performance and balance during the menstrual cycle and the influence of premenstrual symptoms
Fridén, C. (2004) · Figshare · Cited by 4
Sex Hormones and Endurance Exercise in Women: Physiological and Psychological Factors Affecting Performance
MINAHAN, C. L., & Sabapathy, S. (2023) · Springer eBooks · doi:10.1007/978-3-031-21881-1_9 · Cited by 3
Running longer, running stronger: a brief review of endurance exercise and oestrogen
Stone, S. A., Bibens, M. E., Jones, A., & Curtis, K. S. (2014) · Comparative Exercise Physiology · doi:10.3920/cep140007 · Cited by 3
RELATIONS BETWEEN MENSTRUALPHASE AND PERFORMANCE OF AN INTENSE INTERMIT- TENTACTIVITY
Perciavalle, V., Coco, M., Maugeri, A., Gurrisi, L., & Perciavalle, V. (2007) · Cited by 3
Sex Hormones and Substrate Metabolism During Endurance Exercise
Isacco, L., & Boisseau, N. (2023) · Springer eBooks · doi:10.1007/978-3-031-21881-1_2 · Cited by 3
The Effects of Menstrual Cycle Phases on Running Repeated Sprint Ability
Nicola, S. D., Ferrier, B. K., Florida-James, G. D., & Kavaliauskas, M. (2022) · International Journal of Strength and Conditioning · doi:10.47206/ijsc.v2i1.137 · Cited by 2
“The hypothesis was based on previous literature that did not report any differences in RPE between EF and ML (Beidleman et al., 1999; De Souza et al., 1990; Janse de Jonge et al., 2012).”
MethodResultInfluential
Menstrual Cycle and Physical Effort
Więcek, M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.79675 · Cited by 2
“, 45% VO2max [65], 50% VO2max [66], 65% VO2max [65], 70% VO2max [67], as well as 80% VO2max [48].”
BackgroundResultInfluential
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Silva, J. D. D., Farias, D. D. A., Raiol, R., et al. (2018) · Pensar a Prática · doi:10.5216/rpp.v21i3.49976 · Cited by 2
Amenorrhoea
Marshall, L. A. (2000) · doi:10.1002/9780470757093.ch26 · Cited by 2
Menstrual Health in Servicewomen: The Menstrual Cycle, Menstrual Disturbances, and Occupational Consequences
Taipale, R. S., McClung, H. L., Giersch, G. E. W., Cutsem, J. V., Wright, H., O’Leary, T. J., & Greeves, J. P. (2026) · Sports Medicine - Open · doi:10.1186/s40798-025-00963-1 · Cited by 1
“Research in athletic populations indicates that participants with ovarian suppression such as amenorrhea and infrequent menstruation (oligomenorrhea) experience reduction or stagnation in performance and development when compared with those with natural/eumenorrheic menstrual cycles [224–230].”
The effect of endogenous estrogen on Doppler-estimated right ventricular systolic pressure during exercise
Wang, V. N., Ahmed, M., Ciofani, A., et al. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-100 · Cited by 1
Exercise Metabolism and Menstrual Cycle
Fernández-del-Valle, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-15485-0_7 · Cited by 1
The Effect of the Menstrual Cycle on Exercise and Sports Performance
Hicks, K. M., McNulty, K. L., & Ansdell, P. (2023) · Springer eBooks · doi:10.1007/978-3-031-21881-1_11 · Cited by 1
Einflussfaktoren auf die Laktatleistungskurve
Heck, H., & Bartmus, U. (2022) · Springer eBooks · doi:10.1007/978-3-662-59835-1_12 · Cited by 1
Exercise and the Female Reproductive System
Quadagno, D. M. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-016-2_18 · Cited by 1
Effects of estrogen replacement on metabolic factors that influence physical performance in female hypogonadism
Kohrt, W., Pelt, R. V. V., & Gozansky, W. S. (2003) · Journal of Endocrinological Investigation · doi:10.1007/bf03345242 · Cited by 1
Effects of the menstrual cycle and oral contraceptive use on oxygen delivery: aerobic performance, substrate oxidation and iron metabolism (IronFEMME pilot study) = Influencia del ciclo menstrual y del uso de anticonceptivos orales en el suministro de oxígeno: rendimiento aeróbico, oxidación de sustratos y metabolismo del hierro (Estudio piloto IronFEMME)
Moreno, L. B. (2018) · doi:10.20868/upm.thesis.53244 · Cited by 1
The influence of exercise-induced dehydration on cognitive performance in women
Doohan, M. A. (2024) · Queensland University of Technology · doi:10.5204/thesis.eprints.249218 · Cited by 1
The effects of high intensity interval training on submaximal exercise responses and VO2max in active women taking oral contraceptives
Zierke, J. M. (2010) · CSUN ScholarWorks (California State University, Northridge) · Cited by 1
The Female Athlete
Barr, S. I. (2013) · doi:10.1002/9781118692318.ch28
A influência da idade e da reposição hormonal sobre a modulação autonômica do coração e o limiar de anaerobiose.
Neves, V. F. C. (2003) · doi:10.11606/d.82.2003.tde-20082003-111437
A Comparison of Body Composition between Eumenorrheic and Amenorrheic Adolescent Cross-Country Runners
Bonis, M. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000274588.89098.95
The effects of oestradiol administration on energy metabolism during prolonged exercise in amenorrheic athletes
Clark, S. A. (1996) · Victoria University Research Repository (Victoria University)
across the menstrual cycle Resting and exercise ventilatory chemosensitivity
Sheel, A. W., MacNutt, M. J., Souza, M. J. D., et al. (2015)
Self-citation
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VENTILATORY EQUIVALENT RESPONSES DURING FOLLICULAR AND LUTEAL PHASES OF THE MENSTRUAL CYCLE IN ATHLETE WOMEN
Mohsenzadeh, M. (2010)
The Effect of Post-exercise Ethanol Consumption on the Acute Hormonal Response to Heavy Resistance Exercise in Women
Budnar, R. G. (2015) · doi:10.12794/metadc822770
“Women were “phased” so that they completed the experimental treatment sessions during their early follicular phase (days 2-7 after the start of menses) in order to account for hormonal variations during the menstrual cycle (12).”
Background
Sex Differences in Normal Pulmonary Structure and Function at Rest and During Exercise
Harms, C. A., Smith, J. R., & Kurti, S. P. (2015) · Respiratory medicine · doi:10.1007/978-3-319-23998-9_1
The effect of menstrual cycle phase on exercise capacity measured by treadmill exercise test
Yazar, Ş., & Yazıcı, M. (2015) · DergiPark (Istanbul University) · doi:10.15314/tjse.71844
“This finding is contrary to the results of other reports which had noted no difference (5,9,10,11,13,31,38,39).”
BackgroundResult
Effects of the difference between ingestion of Nutrition Supplements for 8 weeks on physical activities and fatigue recovery
Seo, T.-B., Ko, B., 노대성, 김병권, 이진석, Sung, B.-J., & 이종백 (2016) · Korean Journal of Sport Science · doi:10.24985/kjss.2016.27.2.245
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Bera, C., & Ghosh, S. (2020) · Journal of Evolution of Medical and Dental Sciences · doi:10.14260/jemds/2020/795
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Hutchins, K. P. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.207214
The Female Athlete
Dean, E. M., & Ishikawa, S. N. (2014) · Springer eBooks · doi:10.1007/978-1-4899-7427-3_11
Female Athletes
VanHeest, J. L., & Mahoney, C. E. (2007) · Current Sports Medicine Reports · doi:10.1097/01.csmr.0000306466.64843.34
Characteristics of the Menstrual Cycle According to the Sports Groups of the New Generation of Female Athletes
Schuster, S., Palijan, L., & Bobić, T. T. (2023) · Studia sportiva · doi:10.5817/sts2022-2-9
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Porter, M. K., & Duke, J. W. (2023) · Springer eBooks · doi:10.1007/978-3-031-21881-1_4
Validity of SenseWear Armband in assessing the energy expenditure at different exercise intensities during menstrual cycle
Yılmaz, F., Köse, M. G., İŞLER, A. K., & Hazır, T. (2023) · Turkish Journal of Sports Medicine · doi:10.47447/tjsm.0739
MENSTRUAL CYCLE AS AN OBSTACLE TO ACHIEVING MAXIMAL SPORT RESULT
Mladenović, M. P., Karan, V., Klasnja, A. V., Popadić-Gaćeša, J., Barak, O. F., Markovic, O. R., & Markovic, O. R. (2013) · Exercise and Quality of Life · doi:10.31382/eqol201302038m
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Garcia, S., Olenick, A., Jenkins, N. T., & Pearson, R. C. (2025) · Health Promotion & Physical Activity · doi:10.55225/hppa.638
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Bagot, S. (2024) · theses.fr (ABES) · doi:10.70675/13a08bf4ze417z4cb4z80cfz47892200b6c8
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Authors: DE SOUZA, M. J., MAGUIRE, M. S., RUBIN, K. R., & MARESH, C. M.
Affiliations: University of Connecticut (US)
Venue: Medicine & Science in Sports & Exercise
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1990-10
Volume: 22
Issue: 5
Pages: 575-580
ISSN: 0195-9131 (ISSN-L)
DOI: 10.1249/00005768-199010000-00006
OpenAlex: W2068805531
Cited by: 168
References: 0
Citations by year: 2026: 7 · 2025: 5 · 2024: 8 · 2023: 13 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 4
FWCI: 2.70
Type: journal article
Language: en
Open access: closed
Locations: Medicine & Science in Sports & Exercise (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: menstrual cycle, amenorrhea, exercise performance, female runners, eumenorrhea, follicular phase, luteal phase, maximal exercise, submaximal exercise, oxygen consumption, plasma lactate, female athletes, hormonal status
MeSH terms: Adolescent, Adult, Amenorrhea, Energy Metabolism, Exercise Test, Female, Follicular Phase, Heart Rate, Humans, Lactates, Luteal Phase, Menstrual Cycle, Oxygen, Respiration, Running, Exercise

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Effects of menstrual phase and amenorrhea on exercise performance in runners

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