The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Translating Fatigue to Human Performance
Open accessAbstract
Despite flourishing interest in the topic of fatigue-as indicated by the many presentations on fatigue at the 2015 Annual Meeting of the American College of Sports Medicine-surprisingly little is known about its effect on human performance. There are two main reasons for this dilemma: 1) the inability of current terminology to accommodate the scope of the conditions ascribed to fatigue, and 2) a paucity of validated experimental models. In contrast to current practice, a case is made for a unified definition of fatigue to facilitate its management in health and disease. On the basis of the classic two-domain concept of Mosso, fatigue is defined as a disabling symptom in which physical and cognitive function is limited by interactions between performance fatigability and perceived fatigability. As a symptom, fatigue can only be measured by self-report, quantified as either a trait characteristic or a state variable. One consequence of such a definition is that the word fatigue should not be preceded by an adjective (e.g., central, mental, muscle, peripheral, and supraspinal) to suggest the locus of the changes responsible for an observed level of fatigue. Rather, mechanistic studies should be performed with validated experimental models to identify the changes responsible for the reported fatigue. As indicated by three examples (walking endurance in old adults, time trials by endurance athletes, and fatigue in persons with multiple sclerosis) discussed in the review, however, it has proven challenging to develop valid experimental models of fatigue. The proposed framework provides a foundation to address the many gaps in knowledge of how laboratory measures of fatigue and fatigability affect real-world performance.
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Citations
Cites
Spinal and Supraspinal Factors in Human Muscle Fatigue
Gandevia, S. C. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.4.1725 · Cited by 3,855
Monitoring Training Load to Understand Fatigue in Athletes
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Self-citationNeurobiology of muscle fatigue
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Self-citationVision assessment using the NIH Toolbox
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Fatigue and fatigability in neurologic illnesses: Proposal for a unified taxonomy
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Self-citationStretch-shortening cycle: a powerful model to study normal and fatigued muscle
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A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions
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Critical Power: Implications for Determination of V˙O2max and Exercise Tolerance
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Cited by
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Tardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020) · Nutrients · doi:10.3390/nu12010228 · Cited by 541
Ansdell, P., Thomas, K., Hicks, K. M., Hunter, S. K., Howatson, G., & Goodall, S. (2020) · Experimental Physiology · doi:10.1113/ep088548 · Cited by 403
Personalizing exoskeleton assistance while walking in the real world
Slade, P., Kochenderfer, M. J., Delp, S. L., & Collins, S. H. (2022) · Nature · doi:10.1038/s41586-022-05191-1 · Cited by 339
Fatigue and Human Performance: An Updated Framework
Behrens, M., Gube, M., Chaabène, H., Prieske, O., Zénon, A., Broscheid, K., Schega, L., Husmann, F., & Weippert, M. (2022) · Sports Medicine · doi:10.1007/s40279-022-01748-2 · Cited by 437
Development and Validity of the Rating-of-Fatigue Scale
Micklewright, D. P., Gibson, A. S. C., Gladwell, V., & Salman, A. A. (2017) · Sports Medicine · doi:10.1007/s40279-017-0711-5 · Cited by 349
Metadata
- Authors
- ENOKA, R. M., & DUCHATEAU, J.
- Affiliations
- Université Libre de Bruxelles (BE)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2016-11
- Volume
- 48
- Issue
- 11
- Pages
- 2228-2238
- ISSN
- 0195-9131 (ISSN-L)
- PMC
- PMC5035715
- OpenAlex
- W2312572125
- Cited by
- 948
- References
- 76
- Citations by year
- 2026: 144 · 2025: 114 · 2024: 111 · 2023: 102 · 2022: 135 · 2021: 111 · 2020: 76 · 2019: 54 · 2018: 51 · 2017: 32 · 2016: 15
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R03HD079508)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- fatigue, human performance, performance fatigability, perceived fatigability, endurance athletes, multiple sclerosis, fatigue management
- MeSH terms
- Aging, Fatigue, Humans, Multiple Sclerosis, Terminology as Topic, Perception, Physical Endurance, Sports, Walking, Muscle Fatigue
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