Quercetin's Influence on Exercise Performance and Muscle Mitochondrial Biogenesis
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PURPOSE: To determine the influence of 2 wk of quercetin (Q; 1000 mg x d(-1)) compared with placebo (P) supplementation on exercise performance and skeletal muscle mitochondrial biogenesis in untrained, young adult males (N = 26, age = 20.2 +/- 0.4 yr, VO2max = 46.3 +/- 1.2 mL x kg(-1) x min(-1)). METHODS: Using a randomized, crossover design with a 2-wk washout period, subjects provided blood and muscle biopsy samples presupplementation and postsupplementation periods and were given 12-min time trials on 15% graded treadmills after 60 min of moderate exercise preloads at 60% VO2max. RESULTS: Plasma Q levels rose significantly in Q versus P during the 2-wk supplementation period (interaction P value <0.001). During the 12-min trial, the net change in distance achieved was significantly greater during Q (2.9%) compared with P (-1.2%; 29.5 +/- 11.5 vs -11.9 +/- 16.0 m, respectively, P = 0.038). Skeletal muscle messenger RNA expression tended to increase (range = 16-25%) during Q versus P for sirtuin 1 (interaction effect, P = 0.152), peroxisome proliferator-activated receptor gamma coactivator-1alpha (P = 0.192), cytochrome c oxidase (P = 0.081), and citrate synthase (P = 0.166). Muscle mitochondrial DNA (relative copy number per diploid nuclear genome) increased 140 +/- 154 (4.1%) with Q compared with -225 +/- 157 (6.0% decrease) with P (P = 0.098). CONCLUSIONS: In summary, 1000 mg x d(-1) Q versus P for 2 wk by untrained males was associated with a small but significant improvement in 12-min treadmill time trial performance and modest but insignificant increases in the relative copy number of mitochondrial DNA and messenger RNA levels of four genes related to mitochondrial biogenesis.
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Quercetin supplementation (1 g for 2 weeks) improved treadmill performance and markers of mitochondrial biogenesis in untrained adult males.
“Nieman et al. [614] supplemented untrained adult males with 1 g of quercetin in a double-blind fashion for 2 weeks and reported that treadmill performance and markers of mitochondrial biogenesis were improved.”
From ISSN exercise & sports nutrition review update: research & recommendations (2018) · cites this paper as [614]
The Research design section confirms a double-blinded trial, and the Results report significantly improved treadmill performance after 1 g/day of quercetin for two weeks in untrained young adult males. The Results and Discussion describe increases in mitochondrial-biogenesis markers only as nonsignificant trends, so saying the markers “were improved” overstates that finding. Our copy provides no page numbers for these passages. (LLM, conf=0.90)
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References 41 · Cited by 194
- Authors
- NIEMAN, D. C., WILLIAMS, A. S., SHANELY, R. A., JIN, F., MCANULTY, S. R., TRIPLETT, N. T., AUSTIN, M. D., & HENSON, D. A.
- Affiliations
- Appalachian State University (US)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2010-02
- Volume
- 42
- Issue
- 2
- Pages
- 338-345
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2143824660
- Cited by
- 194
- References
- 41
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 12 · 2022: 7 · 2021: 18 · 2020: 17 · 2019: 11 · 2018: 11 · 2017: 7 · 2016: 11 · 2015: 13 · 2014: 17 · 2013: 14 · 2012: 16
- FWCI
- 16.97
- Type
- journal article
- Language
- en
- Open access
- green
- libres.uncg.edu
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- quercetin, exercise performance, mitochondrial DNA copy number, SIRT1, PPARγ coactivator-1α, cytochrome c oxidase, citrate synthase, dietary supplementation, untrained young men, time trial performance
- MeSH terms
- Antioxidants, Double-Blind Method, Exercise Test, Humans, Male, Mitochondria, Quercetin, RNA, Messenger, Muscle, Skeletal, Cross-Over Studies, Dietary Supplements, Athletic Performance, Young Adult
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