Long-Term Physical Activity and Inflammatory Biomarkers in Older Adults
Open accessAbstract
PURPOSE: The purpose of this study was to determine the effects of a 12-month physical activity (PA) intervention on inflammatory biomarkers in elderly men and women. METHODS: Four hundred and twenty-four elderly (age = 70-89 yr), nondisabled, community-dwelling men and women at risk for physical disability were enrolled in a multicenter, single-blind, randomized controlled trial. Participants were randomized to participate in either a 12-month moderate-intensity PA intervention or a successful aging health education intervention. Biomarkers of inflammation (interleukin (IL)-6sR, IL-1sRII, soluble tumor necrosis factor receptors 1 and 2 (sTNFRI, sTNFRII), IL-8, IL-15, adiponectin, IL-1ra, IL-2sRα, and TNFα) were measured at baseline, at 6 months, and at 12 months. RESULTS: A baseline blood sample was successfully collected from 368 participants. After adjustment for gender, clinic site, diabetes status, and baseline outcome measure, IL-8 was the only inflammatory biomarker affected by the PA intervention (P = 0.03). The adjusted mean IL-8 at month 12 was 9.9% (0.87 pg·mL) lower in the PA compared with the successful aging group. Secondary interaction analyses between baseline biomarker status and treatment showed one significant interaction (P = 0.02) such that the PA intervention reduced IL-15 concentrations in participants with a baseline IL-15 above the median value of 1.67 pg·mL. However, these associations were no longer significant after consideration for multiple comparisons. CONCLUSIONS: Overall, this study does not provide definitive evidence for an effect of regular exercise for altering systemic concentrations of the measured inflammatory biomarkers in older adults.
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In the LIFE pilot study, individuals in the physical activity group had reductions in IL-8 but no differences in other inflammatory markers.
“individuals in the physical activity group had reductions in IL-8 but no differences in other inflammatory markers303”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [303]
The Abstract Results report that IL-8 was the only biomarker affected in the main analysis, with a 9.9% lower adjusted level in the physical-activity group at 12 months. But they also report reduced IL-15 in participants with high baseline IL-15, and say neither association remained significant after accounting for multiple comparisons. The claim omits those qualifications. (LLM, conf=0.86)
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References 41 · Cited by 108
- Authors
- BEAVERS, K. M., HSU, F.-C., ISOM, S., KRITCHEVSKY, S. B., CHURCH, T., GOODPASTER, B., PAHOR, M., & NICKLAS, B. J.
- Affiliations
- Atrium Health Wake Forest Baptist (US)
- Wake Forest University Health Sciences (US)
- Pennington Biomedical Research Center (US)
- University of Pittsburgh (US)
- University of Florida (US)
- ORCID
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2010-12
- Volume
- 42
- Issue
- 12
- Pages
- 2189-2196
- ISSN
- 0195-9131 (ISSN-L)
- PMC
- PMC2964389
- OpenAlex
- W2079004380
- Cited by
- 108
- References
- 41
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 16 · 2021: 9 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 11 · 2016: 5 · 2015: 8 · 2014: 7 · 2013: 5 · 2012: 3
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (U01AG22376, U01AG022376, P30AG-21332, R01AG027529, P30AG028740, P30AG021332)
- National Center for Research Resources (UL1RR029890)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- physical activity interventions, inflammatory markers, older adults, interleukin-8, IL-15, soluble tumor necrosis factor receptor, adiponectin, TNF-α, successful aging, health education, exercise and inflammation
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Inflammation, Interleukins, Male, United States, Biomarkers, Exercise, Cytokines, Receptors, Tumor Necrosis Factor, Tumor Necrosis Factors, Adiponectin
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