Effects of tri-, di- and monobutyltin on synaptic parameters of the cholinergic system in the cerebral cortex of mice
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Triorganotin compounds like tributyltin have been reported to be biodegraded to diorganotin, monoorganotin and then inorganic tin in animals after they have been ingested. Effects of tributyltin, dibutyltin and monobutyltin on various cholinergic parameters that are involved in synaptic transmission in the mouse cerebral cortex were investigated in vitro. Tributyltin and dibutyltin, but not monobutyltin, inhibited the activity of choline acetyltransferase, both the high-affinity and low-affinity uptakes of choline into synaptosomes, and the binding of [3H]quinuclidinyl benzilate to muscarinic acetylcholine receptors. Tributyltin and dibutyltin, but not monobutyltin, had a slightly suppressive effect on the K(+)-induced release and synthesis of acetylcholine in slices of the cortex. All three butyltins at concentrations from 10(-6) to 10(-4) M had no effect on the activity of acetylcholinesterase. The extent of the inhibitory effects on the cholinergic parameters, apart from the activity of acetylcholinesterase, was slightly greater in the case of tributyltin than dibutyltin, in particularly at the highest concentration (10(-4) M) tested. Therefore, it is concluded that tributyltin metabolites inhibit various parameters of cholinergic activity with a potency ranking of tributyltin > dibutyltin > monobutyltin.
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Organotin compounds alter inhibitory synaptic currents and cholinergic transmission, suggesting broader neuromodulatory instability.
“Organotin compounds add a further layer of disruption by altering inhibitory synaptic currents and cholinergic transmission, suggesting broader neuromodulatory instability (Kobayashi et al., 1996; Yavuz et al., 2023).”
From Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction (2026) · cites this paper as Kobayashi et al., 1996
In mice, tributyltin metabolites interfere with cholinergic signaling pathways in the cerebral cortex, resulting in disturbed synaptic transmission.
“In mice, tributyltin metabolites have been shown to interfere with cholinergic signaling pathways in the cerebral cortex, resulting in disturbed synaptic transmission (Kobayashi et al., 1996).”
From Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction (2026) · cites this paper as Kobayashi et al., 1996
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Seralini, G.-E., & Jungers, G. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.07.014 · Cited by 57 · see citing works
Jocsak, G., Kiss, D. S., Alymbaeva, D., Diebald, A., Zsarnovszky, A., Heinzlmann, A., & Bartha, T. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1821381 · Cited by 1 · see citing works
“In mice, tributyltin metabolites have been shown to interfere with cholinergic signaling pathways in the cerebral cortex, resulting in disturbed synaptic transmission (Kobayashi et al., 1996).”
- Authors
- Kobayashi, H., Suzuki, T., Kasashima, Y., Motegi, A., Sato, I., Matsusaka, N., Ono, N., Miura, A., Saito, F., & Saito, S.-Y.
- Affiliations
- Iwate University (JP)
- Koiwai FARM, Ltd. (Japan) (JP)
- Venue
- Japanese Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1996
- Volume
- 72
- Issue
- 4
- Pages
- 317-324
- ISSN
- 0021-5198 (ISSN-L)
- OpenAlex
- W2043061879
- Cited by
- 24
- References
- 0
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- The Japanese Journal of Pharmacology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Physical Sciences › Chemistry › Organic Chemistry › Organometallic Compounds Synthesis and Characterization
- Keywords
- tributyltin, dibutyltin, monobutyltin, organotin compounds, cholinergic system, cerebral cortex, choline acetyltransferase, choline uptake, muscarinic receptors, acetylcholine release, acetylcholinesterase, synaptic transmission, neurotoxicity, quinuclidinyl benzilate
- MeSH terms
- Acetylcholinesterase, Animals, Cerebral Cortex, Choline, Male, Mice, Inbred ICR, Organotin Compounds, Parasympathetic Nervous System, Quinuclidinyl Benzilate, Receptors, Muscarinic, Synapses, Trialkyltin Compounds, Muscarinic Agonists, Mice, In Vitro Techniques
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