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Cited by 444

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Purinergic Signalling: Pathophysiological Roles

Open access
Maria P., Abbracchio, Geoffrey, Burnstock·1998·Japanese Journal of Pharmacology

Abstract

In this review, after a summary of the history and current status of the receptors involved in purinergic signalling, we focus on the distribution and physiological roles of purines and pyrimidines in both short-term events such as neurotransmission, exocrine and endocrine secretion and regulation of immune cell function, and long-term events such as cell growth, differentiation and proliferation in development and regeneration. Finally, the protective roles of nucleosides and nucleotides in events such as cancer, ischemia, wound healing, drug toxicity, inflammation and pain are explored and some suggestions made for future developments in this rapidly expanding field, with particular emphasis on the involvement of selective agonists and antagonists for purinergic receptor subtypes in therapeutic strategies.

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Crossref · 10.1254/jjp.78.113

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Metadata

Authors
Maria P., A., & Geoffrey, B.
Venue
Japanese Journal of Pharmacology
Publisher
Elsevier BV
Published
1998
Volume
78
Issue
2
Pages
113-145
ISSN
0021-5198 (ISSN-L)
OpenAlex
W2094319340
Cited by
444
References
2
FWCI
14.58
Type
journal article
Language
en
Open access
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