Intracerebroventricular injection of microglia protects against focal brain ischemia
Open accessAbstract
Microglia are macrophage-like phagocytic cells in the brain parenchyma. However, microglial function after neurodegeneration is not fully understood. In this study, occlusion of the middle cerebral artery (MCA) and reperfusion caused massive neuronal loss in the rat cerebral cortex and striatum after 3 days. When exogenous microglia were microinjected into the intracerebroventricle during MCA occlusion, neurodegenerative areas significantly decreased. At that time, migrated microglia were detected in the ischemic lesion. These results suggest that exogenous microglia can migrate into brain parenchyma and then protect against neurodegeneration induced by MCA occlusion and reperfusion.
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Intracerebroventricular injection of microglia protected the BBB and neurons against focal brain ischemia in a rat model.
“Besides that, Kitamura and colleagues demonstrated in a rat model that the intracerebroventricular injection of microglia protected the BBB and neurons against focal brain ischemia (Kitamura et al., 2004).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Kitamura et al., 2004
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References 13 · Cited by 104
Research works printed but not linked: 3
- Kettenmann H, Ransom BR, editors. Neuroglia. New York and Oxford: Oxford University Press; 1995.
- Kitamura Y, Shibagaki K, Takata K, et al. Involvement of WAVE and Rac1 in the phagocytosis of amyloid-b (1 -42) in rat microglia. J Pharmacol Sci. 2003;92:115-123.
- Paxinos G, Watson C, editors. The rat brain in stereotaxic coordinates. 2nd ed. North Ryde (Australia): Academic Press; 1986.
- Authors
- Kitamura, Y., Takata, K., Inden, M., Tsuchiya, D., Yanagisawa, D., Nakata, J., & Taniguchi, T.
- Affiliations
- Kyoto Pharmaceutical University (JP)
- Venue
- Journal of Pharmacological Sciences
- Publisher
- Japanese Pharmacological Society
- Published
- 2004
- Volume
- 94
- Issue
- 2
- Pages
- 203-206
- ISSN
- 1347-8613 (ISSN-L)
- 1347-8648
- OpenAlex
- W2062216455
- Cited by
- 104
- References
- 13
- Citations by year
- 2024: 1 · 2023: 6 · 2022: 2 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 8 · 2012: 12
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Promotion and Mutual Aid Corporation for Private Schools of Japan
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microglia, focal cerebral ischemia, middle cerebral artery occlusion, ischemia-reperfusion injury, neuroprotection, microglial migration, neurodegeneration, intracerebroventricular administration, striatum, cerebral cortex
- MeSH terms
- Animals, Brain Ischemia, Injections, Intraventricular, Brain Tissue Transplantation, Rats, Wistar, Microglia, Cell Transplantation, Rats
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