The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Heterogeneity of therapeutic responses in asthma
Abstract
Asthma is a complex clinical syndrome with multiple genetic and environmental factors contributing to its phenotypic expression. This aetiological heterogeneity adds to the complexity when addressing variation in the response to anti-asthma treatment. Currently, there are three main lines of treatment available: (i) inhaled glucocorticoids which have multiple mechanisms of action; (ii) beta 2-agonists which are very effective bronchodilators and act predominantly on airway smooth muscle; and (iii) cysteinyl-leukotriene inhibitors. Analysis of the repeatability (r) of the treatment response, defined as the fraction of the total population variance which results from among-individual differences, shows values of r between 60-80% indicating that a substantial fraction of the variance of the treatment response could be genetic in nature. Among the sources of variability that could contribute to the observed heterogeneity in the response to treatment are the degree of underlying inflammation, such as in glucocorticoid resistance, and polymorphisms in the genes encoding the drug target, such as beta 2-adrenoceptor and 5-lipoxygenase.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Introduction to Quantitative Genetics.
Edwards, A. W. F., & Falconer, D. S. (1982) · Biometrics · doi:10.2307/2529912 · Cited by 21,447
Genetics and Analysis of Quantitative Traits
(2002) · Journal of Animal Breeding and Genetics · doi:10.1046/j.1439-0388.2002.00356.x · Cited by 6,092
Unrepeatable Repeatabilities: A Common Mistake
Lessells, C. M., & Boag, P. T. (1987) · The Auk · doi:10.2307/4087240 · Cited by 2,916
Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation
Samuelsson, B. (1983) · Science · doi:10.1126/science.6301011 · Cited by 2,843
Guidelines for the diagnosis and management of asthma.
Solomon, P. A. (1992) · PubMed · Cited by 2,004
Regular inhaled beta-agonist treatment in bronchial asthma
Sears, M. R., Taylor, D. R., Print, C. G., Lake, D. C., Li, Q., Flannery, E. M., Yates, D. M., Lucas, M. K., & Herbison, G. P. (1990) · The Lancet · doi:10.1016/0140-6736(90)93098-a · Cited by 1,065
Mutations in the Gene Encoding for the β 2 -adrenergic Receptor in Normal and Asthmatic Subjects
Reihsaus, E., Innis, M., MacIntyre, N., & Liggett, S. B. (1993) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/8.3.334 · Cited by 617
Martinez, F. D., Graves, P. E., Baldini, M., Solomon, S., & Erickson, R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119874 · Cited by 605
Drazen, J. M., Yandava, C. N., Dubé, L., Szczerback, N., Hippensteel, R., Pillari, A., Israel, E., Schork, N., Silverman, E. S., Katz, D. A., et al. (1999) · Nature Genetics · doi:10.1038/9680 · Cited by 560
Self-citationAssociation of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β
Leung, D. Y. M., Hamid, Q., Vottero, A., Szefler, S. J., Surs, W., Minshall, E., Chrousos, G. P., & Klemm, D. J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1567 · Cited by 415
Cited by
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650
Genomewide Association between GLCCI1 and Response to Glucocorticoid Therapy in Asthma
Tantisira, K. G., Lasky-Su, J., Harada, M., Murphy, A., Litonjua, A. A., Himes, B. E., Lange, C., Lazarus, R., Sylvia, J., Klanderman, B., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa0911353 · Cited by 366
Ortega, V. E., & Meyers, D. A. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.040 · Cited by 237
Gulliver, T., Morton, R., & Eid, N. (2007) · Pediatric Drugs · doi:10.2165/00148581-200709030-00007 · Cited by 47
Metadata
- Authors
- Drazen, J. M., Silverman, E. K., & Lee, T. H.
- Venue
- British Medical Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01-01
- Volume
- 56
- Issue
- 4
- Pages
- 1054-1070
- ISSN
- 0007-1420 (ISSN-L)
- 1471-8391
- OpenAlex
- W2030676726
- Cited by
- 318
- References
- 30
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Heterogeneity of therapeutic responses in asthma. https://app.cochat.ai/papers/10.1258/0007142001903535
- The paper
- Drazen, J. M., Silverman, E. K., & Lee, T. H. (2000). Heterogeneity of therapeutic responses in asthma. British Medical Bulletin. https://doi.org/10.1258/0007142001903535
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
