The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Folic acid deficiency and cancer: mechanisms of DNA instability
Abstract
Folic acid deficiency in humans has been linked with megaloblastic anaemia, neural tube defects in the neonate, and heart disease. Folate has also been implicated in the development of cancer, especially cancer of the colorectum. There appear to be two principal mechanisms through which low folate status may increase the risk of malignancy. Folate deficiency, by reducing intracellular S-adenosylmethionine (SAM), can alter cytosine methylation in DNA, leading to inappropriate activation of proto-oncogenes and induction of malignant transformation. Alternatively, folic acid is crucial for normal DNA synthesis and repair. Folate deficiency may cause an imbalance in DNA precursors, uracil misincorporation into DNA, and chromosome breakage. This chapter briefly describes the epidemiological data supporting the involvement of folic acid in the aetiology of cancer. It also assesses the evidence from cellular, animal and human studies that folic acid can modulate DNA by such mechanisms.
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Cited by
Role of Folate in Colon Cancer Development and Progression
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Combined Prenatal Pesticide Exposure and Folic Acid Intake in Relation to Autism Spectrum Disorder
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The C/EBPδ tumor suppressor is silenced by hypermethylation in acute myeloid leukemia
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Metadata
- Authors
- Duthie, S. J.
- Venue
- British Medical Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01-01
- Volume
- 55
- Issue
- 3
- Pages
- 578-592
- ISSN
- 0007-1420 (ISSN-L)
- 1471-8391
- OpenAlex
- W2161069925
- Cited by
- 445
- References
- 47
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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