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Inherited seborrheic dermatitis - a new mutant in mice
Abstract
A new mutation, affecting skin and hair, occurred in an expansion colony of Him:OF1 mice. Test crosses showed that a single autosomal recessive gene was responsible for this trait. Homozygotes have sparse greasy fur and lower viability and fertility than normal littermates. Histological observations showed hypertrophy of sebaceous glands, hyperkeratosis, parakeratosis, acanthosis and signs of inflammation. The disease was named 'inherited seborrheic dermatitis' and the gene name seb is proposed.
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In the autosomal recessive "inherited seborrheic dermatitis" (seb) mice, a spontaneous mutation caused seborrhea, rough coat, alopecia, growth retardation, and sometimes abnormal pigmentation in homozygous mutants.
“In the autosomal recessive “inherited seborrheic dermatitis” (seb) mice, a spontaneous mutation in the outbred Him:OF1 mice caused seborrhea, rough coat, alopecia, growth retardation, and sometimes abnormal pigmentation in homozygous mutants [80].”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [80]
Neither yeasts nor dermatophytes were detected in seb mice.
“Neither yeasts nor dermatophytes were detected.”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [80]
Histological examination of seb mice revealed enlarged sebaceous glands, hyperkeratosis, parakeratosis, acanthosis and inflammatory infiltrates in the epidermis and dermis.
“Histological examination revealed enlarged sebaceous glands, hyperkeratosis, parakeratosis, acanthosis and inflammatory infiltrates in the epidermis and dermis.”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [80]
The seb mice were the first animal model of SD to show a clear mode of inheritance, though the underlying mutation remains unidentified.
“These mice were the first animal model of SD to show a clear mode of inheritance, though the underlying mutation remains unidentified [80,81].”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [80]
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Seborrheic Dermatitis and Dandruff: A Comprehensive Review
(2015) · Journal of Clinical and Investigative Dermatology · doi:10.13188/2373-1044.1000019 · Cited by 398
Metadata
- Authors
- Höger, H., Gialamas, J., & Adamiker, D.
- Affiliations
- University of Vienna (AT)
- Venue
- Laboratory Animals
- Publisher
- SAGE Publications
- Published
- 1987-10-01
- Volume
- 21
- Issue
- 4
- Pages
- 299-305
- ISSN
- 0023-6772 (ISSN-L)
- 1758-1117
- OpenAlex
- W2020153044
- Cited by
- 10
- References
- 0
- Citations by year
- 2022: 1 · 2021: 1 · 2019: 2 · 2017: 1 · 2015: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Laboratory Animals (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Genetic and rare skin diseases.
- Health Sciences › Medicine › Dermatology › Nail Diseases and Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- seb gene, mouse mutants, sebaceous gland hypertrophy, hyperkeratosis, parakeratosis, epidermal hyperplasia, autosomal recessive inheritance, skin histopathology
- MeSH terms
- Animals, Female, Male, Mice, Mutant Strains, Rodent Diseases, Dermatitis, Seborrheic, Mice
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