Postprandial plasma bile acid responses in normal weight and obese subjects
Abstract
BACKGROUND: Bile acids can act as signalling molecules via various receptors including the nuclear farnesoid X receptor (FXR) and pregnane X receptor (PXR), and the cell surface G-protein-coupled receptor TGR5. The signalling has been implicated in the release of peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), which improves glycaemic control and energy expenditure. We investigated whether morbidly obese subjects have altered postprandial bile acid responses in comparison to normal weight subjects. METHOD: Blood samples were taken every 30 min from 0 to 180 min following a 400 kcal test meal. Samples were taken from 12 normal weight subjects with a body mass index (BMI) of 23.2 (2.8) kg/m(2) (median [interquartile range (IQR)]) and seven obese patients with a BMI of 47.2 (7.2) kg/m(2). Fractionated bile acids were measured on these samples using high-performance liquid chromatography tandem mass spectrometry. RESULTS: The obese subjects showed a lower postprandial response in total bile acids compared with the normal weight subjects. An increase of 6.4 (5.0) and 2.6 (3.3) micromol/L (median [IQR]) in normal weight and obese subjects was observed, respectively (P = 0.02). The difference was predominantly due to the glycine-conjugated fraction (P = 0.03). There was no difference in the increase of the unconjugated or taurine-conjugated fractions. CONCLUSIONS: The decreased postprandial bile acid response in obese subjects compared with normal weight subjects may partly explain the suboptimal GLP-1 and PYY responses and could affect appetite, glycaemic control and energy expenditure.
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The postprandial bile acid response is blunted in obesity and enhanced after RYGB.
“The postprandial bile acid response is blunted in obesity and enhanced after RYGB, indicating that this response might be important for inducing satiety, reduced food intake, and lower body weight (Ahmad et al., 2013; Glicksman et al., 2010).”
From Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015) · cites this paper as Glicksman et al., 2010
Increased circulating levels of primary and secondary bile acids have been observed after RYGB.
“Increased circulating levels of primary and secondary bile acids have been observed after RYGB (Ahmad et al., 2013; Glicksman et al., 2010; Kohli et al., 2013; Patti et al., 2009) and have been linked to increased GLP-1 and reduced glucose and triglyceride levels (Nakatani et al., 2009; Patti et al., 2009; Pournaras et al., 2012; Simonen et al., 2012).”
From Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015) · cites this paper as Glicksman et al., 2010
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References 7 · Cited by 94
- Authors
- Glicksman, C., Pournaras, D. J., Wright, M., Roberts, R., Mahon, D., Welbourn, R., Sherwood, R., Alaghband-Zadeh, J., & le Roux, C. W.
- Affiliations
- King's College Hospital NHS Foundation Trust (GB)
- Musgrove Park Hospital (GB)
- King's College London (GB)
- Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS
- Venue
- Annals of Clinical Biochemistry International Journal of Laboratory Medicine
- Publisher
- SAGE Publications
- Published
- 2010-07-01
- Volume
- 47
- Issue
- 5
- Pages
- 482-484
- ISSN
- 0004-5632 (ISSN-L)
- 1758-1001
- OpenAlex
- W2007563846
- Cited by
- 94
- References
- 7
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 13 · 2014: 7 · 2013: 6 · 2012: 2
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Clinical Biochemistry International Journal of Laboratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- obesity, morbid obesity, glycine-conjugated bile acids, taurine-conjugated bile acids, unconjugated bile acids, glucagon-like peptide-1, peptide YY, farnesoid X receptor, pregnane X receptor, TGR5, appetite regulation, glycemic control, energy expenditure
- MeSH terms
- Bile Acids and Salts, Body Weight, Female, Humans, Male, Middle Aged, Obesity, Case-Control Studies, Postprandial Period, Young Adult
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