Alternative polyadenylation: New insights from global analyses
Open accessAbstract
Recent studies have revealed widespread mRNA alternative polyadenylation (APA) in eukaryotes and its dynamic spatial and temporal regulation. APA not only generates proteomic and functional diversity, but also plays important roles in regulating gene expression. Global deregulation of APA has been demonstrated in a variety of human diseases. Recent exciting advances in the field have been made possible in a large part by high throughput analyses using newly developed experimental tools. Here I review the recent progress in global studies of APA and the insights that have emerged from these and other studies that use more conventional methods.
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The 3′ UTR harbors polyadenylation signals, which can generate multiple isoforms with distinct 3′ ends through alternative polyadenylation.
“The 3′ untranslated region (UTR) harbors regulatory regions called polyadenylation signals (PASs), which can generate multiple isoforms with distinct 3′ ends through alternative polyadenylation (APA)39–41.”
From Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation (2025) · cites this paper as [41]
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References 116 · Cited by 212
- Authors
- Shi, Y.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Shi, Yongsheng
- ORCID
- Shi, Yongsheng
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-10-24
- Volume
- 18
- Issue
- 12
- Pages
- 2105-2117
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- PMC
- PMC3504663
- OpenAlex
- W2172208515
- Cited by
- 212
- References
- 116
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 16 · 2021: 19 · 2020: 12 · 2019: 19 · 2018: 12 · 2017: 31 · 2016: 17 · 2015: 12 · 2014: 28 · 2013: 21
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- RNA (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs (CDP 12-186)
- National Institutes of Health
- University of California, Irvine
- National Institute of General Medical Sciences (R01GM090056)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- alternative polyadenylation, mRNA 3' end processing, gene expression regulation, proteomic diversity, eukaryotic gene regulation
- MeSH terms
- Animals, Disease, Gene Expression Regulation, Humans, Models, Biological, Neoplasms, RNA, Messenger, RNA 3' End Processing, Polyadenylation
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