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MicroRNA dynamics at the onset of primordial germ and somatic cell sex differentiation during mouse embryonic gonad development

Fernández-Pérez, Daniel, Brieño-Enríquez, Miguel A., Isoler-Alcaraz, Javier, Larriba, Eduardo, del Mazo, Jesús·2018·RNA
DOI 10.1261/rna.062869.117PMC PMC5824349
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Abstract

In mammals, commitment and specification of germ cell lines involves complex programs that include sex differentiation, control of proliferation, and meiotic initiation. Regulation of these processes is genetically controlled by fine-tuned mechanisms of gene regulation in which microRNAs (miRNAs) are involved. We have characterized, by small-RNA-seq and bioinformatics analyses, the miRNA expression patterns of male and female mouse primordial germ cells (PGCs) and gonadal somatic cells at embryonic stages E11.5, E12.5, and E13.5. Differential expression analyses revealed differences in the regulation of key miRNA clusters such as miR-199-214, miR-182-183-96, and miR-34c-5p, whose targets have defined roles during gonadal sexual determination in both germ and somatic cells. Extensive analyses of miRNA sequences revealed an increase in noncanonical isoforms on PGCs at E12.5 and dramatic changes of 3′ isomiR expression and 3′ nontemplate nucleotide additions in female PGCs at E13.5. Additionally, RT-qPCR analyses of genes encoding proteins involved in miRNA biogenesis and 3′ nucleotide addition uncovered sexually and developmentally specific expression, characterized by the decay of Drosha, Dgcr8, and Xpo5 expression along gonadal development. These results demonstrate that miRNAs, their isomiRs, and miRNA machinery are differentially regulated and participate actively in gonadal sexual differentiation in both PGCs and gonadal somatic cells.

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  • The expression of isomiRs appears to be regulated in a developmental and tissue-specific manner.

    “The expression of isomiRs appears to be regulated in a developmental and tissue‐specific manner (Fernández‐Pérez, Brieño‐Enríquez, Isoler‐Alcaraz, Larriba, & del Mazo, 2017; Fernandez‐Valverde, Taft, & Mattick, 2010; Woldemariam et al., 2019; Wyman et al., 2011).”

    From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Fernández‐Pérez, Brieño‐Enríquez, Isoler‐Alcaraz, Larriba, & del Mazo, 2017

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Authors
Fernández-Pérez, D., Brieño-Enríquez, M. A., Isoler-Alcaraz, J., Larriba, E., & del Mazo, J.
ORCID
Venue
RNA
Publisher
Cold Spring Harbor Laboratory
Published
2017-11-29
Volume
24
Issue
3
Pages
287-303
ISSN
  • 1355-8382
  • 1469-9001
DOI
10.1261/rna.062869.117
PMC
PMC5824349
Cited by
36
References
4
Language
en
Funders
  • Postdoctoral fellowship
  • Empire State Stem Cell Fund
  • New York State Department of Health (C30293GG)
  • MINECO (BFU2013-42164-R)
  • Centro de Investigaciones Biológicas
  • CAM (PROEX: 054/15)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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