miR-200b mediates post-transcriptional repression of ZFHX1B
Abstract
MicroRNAs have important functions during animal development and homeostasis through post-transcriptional regulation of their cognate mRNA targets. ZFHX1B is a transcriptional repressor involved in the TGFβ signaling pathway and in processes of epithelial to mesenchymal transition via regulation of E-cadherin. We show that Zfhx1b and miR-200b are regionally coexpressed in the adult mouse brain and that miR-200b represses the expression of Zfhx1b via multiple sequence elements present in the 3′-untranslated region. Overexpression of miR-200b leads to repression of endogenous ZFHX1B, and inhibition of miR-200b relieves the repression of ZFHX1B. In accordance with these findings, miR-200b regulates the activity of the E-cadherin promoter.
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Regional coexpression of miRNAs and their targets has been reported.
“Regional coexpression of miRNAs and their targets has been reported.”
From MicroRNA expression in the adult mouse central nervous system (2008) · cites this paper as Christoffersen et al. 2007
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- Humphreys, D.T., Westman, B.J., Martin, D.I., and Preiss, T. 2005. MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function. Proc. Natl. Acad. Sci. 102: 16961-16966.
- Wakamatsu, N., Yamada, Y., Yamada, K., Ono, T., Nomura, N., Taniguchi, H., Kitoh, H., Mutoh, N., Yamanaka, T., Mushiake, K., miR-200b regulation of ZFHX1B www.rnajournal.org 1177 Cold Spring Harbor Laboratory Press on July 23, 2023 -Published by rnajournal.cshlp.org Downloaded from et al. 2001. Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease. Nat. Genet. 27: 369-370.
- Wu, L., Fan, J., and Belasco, J.G. 2006. MicroRNAs direct rapid deadenylation of mRNA. Proc. Natl. Acad. Sci. 103: 4034-4039.
Cited by
Sorted by citations
Epithelial-Mesenchymal Transitions in Development and Disease
Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931 · see citing works
Epithelial-mesenchymal transitions: insights from development
Lim, J., & Thiery, J. P. (2012) · Development · doi:10.1242/dev.071209 · Cited by 661 · see citing works
MicroRNA expression in the adult mouse central nervous system
Bak, M., Silahtaroglu, A., Møller, M., Christensen, M., Rath, M. F., Skryabin, B., Tommerup, N., & Kauppinen, S. (2008) · RNA · doi:10.1261/rna.783108 · Cited by 463 · see citing works
Self-citationMicroRNA-regulated pathways associated with endometriosis
Ohlsson Teague, E. M. C., Van der Hoek, K. H., Van der Hoek, M. B., Perry, N., Wagaarachchi, P., Robertson, S. A., Print, C. G., & Hull, L. M. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0387 · Cited by 357 · see citing works
The role of microRNAs in endometriosis and associated reproductive conditions
Ohlsson Teague, E. M. C., Print, C. G., & Hull, M. L. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmp034 · Cited by 309 · see citing works
- Authors
- Christoffersen, N. R., Silahtaroglu, A., Ørom, U. A., Kauppinen, S., & Lund, A. H.
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2007-06-21
- Volume
- 13
- Issue
- 8
- Pages
- 1172-1178
- ISSN
- 1355-8382
- 1469-9001
- Cited by
- 140
- References
- 0
- Language
- en
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