Expression of TBX3 in Hepatocellular Carcinoma and Its Clinical Implication
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BACKGROUND Hepatocellular carcinoma (HCC) is the fifth most common malignancy in China, and China's annual number of new cases accounts for about 45% of the world total. This research was aimed to study the expression of TBX3 protein in HCC and exploring its clinical significance. MATERIAL AND METHODS We collected tumor tissues and adjacent non-tumoral tissues of 174 patients with HCC undergoing surgical resection. The expression of TBX3 protein in different tissues and cell lines in vitro (LO2, HHL-5, MHC97-L, MHC97-H) was detected by immunohistochemistry or Western blotting, and the relationship between TBX3 expression and clinical data of patients with HCC was analyzed. RESULTS The expression of TBX3 protein in HCC was significantly correlated with histological grade, tumor size, cancer cell metastasis, hepatitis B surface antigen, and the expression of Ki-67 in tumor tissues (P<0.05), and it was positively correlated with serum AFP level (r=0.766, P<0.05). The expression of TBX3 increased with increased histological grade in HCC (P<0.05). Cox regression analysis showed that the expression of TBX3 protein in HCC was an independent risk factor for prognosis (OR=0.524, 95% CI=0.283-0.964). The 5-year survival rate of patients with HCC that highly expressed TBX3 protein was 20.83%, which was significantly lower than the 40.20% rate in patients with low expression (P<0.05). CONCLUSIONS The expression of TBX3 in HCC patients undergoing surgical resection is high, and its expression increases with the degree of tumor differentiation. It is related to the metastasis of tumor cells and is positively correlated with the serum level of AFP and may affect the survival time of HCC patients undergoing surgical resection.
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TBX3 can either promote tumor development or suppress tumor progression, depending on the tumor type.
“It has been reported TBX3 can either promote tumor development or suppress tumor progression, depending on the tumor type.[12, 21-24]”
From TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis (2021) · cites this paper as [23]
The Background and Discussion describe TBX3 as overexpressed in several cancers and as promoting tumor development in hepatocellular carcinoma. They do not report TBX3 suppressing tumor progression in another tumor type, so the claimed tumor-type-dependent reversal is unsupported by this source. (LLM, conf=0.86)
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Cites
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“In the liver, TBX3 can inhibit the priming sequence of p19ARF in a specific way, thereby inhibiting the expression of p19ARF protein [20].”
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The roles and regulation of TBX3 in development and disease
Khan, S. F., Damerell, V., Omar, R., Du Toit, M., Khan, M., Maranyane, H. M., Mlaza, M., Bleloch, J., Bellis, C., Sahm, B. D. B., et al. (2020) · Gene · doi:10.1016/j.gene.2019.144223 · Cited by 99 · see citing works
Liang, B., Zhou, Y., Qian, M., Xu, M., Wang, J., Zhang, Y., Song, X., Wang, H., Lin, S., Ren, C., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.01.044 · Cited by 55 · see citing works
- Authors
- Li, Z., Wang, Y., Duan, S., Shi, Y., Li, S., Zhang, X., & Ren, J.
- Affiliations
- Inner Mongolia Medical University (CN)
- Corresponding author
- Zhang, Xiaoshan
- Venue
- Medical Science Monitor
- Published
- 2018-12-22
- Volume
- 24
- Pages
- 9324-9333
- ISSN
- 1234-1010 (ISSN-L)
- 1643-3750
- PMC
- PMC6320639
- OpenAlex
- W2906327764
- Cited by
- 11
- References
- 3
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Medical Science Monitor (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- TBX3, hepatocellular carcinoma, protein expression, prognostic factors, histological grade, metastasis, alpha-fetoprotein, survival, surgical resection, Ki-67
- MeSH terms
- Adult, Aged, China, Female, Carcinoma, Hepatocellular, Humans, Immunohistochemistry, Liver Neoplasms, Male, Middle Aged, Prognosis, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Survival Rate, Proportional Hazards Models, T-Box Domain Proteins, Kaplan-Meier Estimate, Transcriptome, Neoplasm Grading
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