Differentiation of beta thalassemia trait from iron deficiency anemia by hematological indices
Open accessAbstract
Objective: We aimed at finding out reliable parameter in the differentiation of iron deficiency anemia (IDA) and beta-thalassemia trait (?-TT) in the adult population subjected to Saudi Arabian Premarital Screening Program.Methods: A total of 620 adults (age range 21-36 years) reported during February 2012 to November 2012. Tests for serum iron and ferritin were carried out in individuals showing low hemoglobin (Hb). All the selected subjects
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Existing formulas were not designed to differentiate structural hemoglobin variants, combinations of multiple hemoglobinopathies, or cases with a hemoglobinopathy and concomitant iron deficiency.
“These formulas were not designed to differentiate structural hemoglobin variants, combinations of multiple hemoglobinopathies, or cases with a hemoglobinopathy and concomitant iron deficiency (20,21).”
From Machine Learning-Based Prediction of Hemoglobinopathies Using Complete Blood Count Data (2024) · cites this paper as [21]
The Introduction describes the indices and formulas as tools for differentiating iron deficiency anemia from β-thalassemia trait. The Discussion notes that coexisting iron deficiency can complicate diagnosis, but the paper does not establish that existing formulas were not designed for structural hemoglobin variants, multiple hemoglobinopathies, or all cases of concomitant iron deficiency. No page numbers are available in our copy. (LLM, conf=0.78)
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Research works printed but not linked: 21
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Cited by
Sorted by citations
Machine Learning-Based Prediction of Hemoglobinopathies Using Complete Blood Count Data
Schipper, A., Rutten, M., van Gammeren, A., Harteveld, C. L., Urrechaga, E., Weerkamp, F., den Besten, G., Krabbe, J., Slomp, J., Schoonen, L., et al. (2024) · Clinical Chemistry · doi:10.1093/clinchem/hvae081 · Cited by 33 · see citing works
- Authors
- Jameel, T. A., Baig, M., Ahmed, I., Hussain, M. B., & Doghaim Alkhamaly, M. B.
- Affiliations
- King Abdulaziz University (SA)
- Corresponding author
- Jameel, Tahir Ahmed
- ORCID
- Jameel, Tahir Ahmed
- Venue
- Pakistan Journal of Medical Sciences
- Publisher
- Pakistan Journal of Medical Sciences
- Published
- 2017-06-30
- Volume
- 33
- Issue
- 3
- Pages
- 665-669
- ISSN
- 1681-715X (ISSN-L)
- 1682-024X
- PMC
- PMC5510123
- OpenAlex
- W2625619844
- Cited by
- 79
- References
- 0
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 13 · 2023: 13 · 2022: 11 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 4
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Pakistan Journal of Medical Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- beta-thalassemia trait, iron deficiency anemia, differential diagnosis, red cell distribution width, mean corpuscular volume, microcytic hypochromic anemia, premarital screening, Saudi population, hematological parameters
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