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Cited by 35Nuclear Structure and FunctionMicrotubule and mitosis dynamicsSkin and Cellular Biology Research

Chain reaction: LINC complexes and nuclear positioning

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Burke, Brian·2019·F1000Research
DOI 10.12688/f1000research.16877.1PMC PMC6357990
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Abstract

Nuclear positioning plays an essential role in defining cell architecture and behaviour in both development and disease, and nuclear location frequently adjusts according to internal and external cues. For instance, during periods of migration in many cell types, the nucleus may be actively repositioned behind the microtubule-organising centre. Nuclear movement, for the most part, is dependent upon coupling of the cytoskeleton to the nuclear periphery. This is accomplished largely through SUN and KASH domain proteins, which together assemble to form LINC (linker of the nucleoskeleton and cytoskeleton) complexes spanning the nuclear envelope. SUN proteins of the inner nuclear membrane provide a connection to nuclear structures while acting as a tether for outer nuclear membrane KASH proteins. The latter contain binding sites for diverse cytoskeletal components. Recent publications highlight new aspects of LINC complex regulation revealing that the interplay between SUN and KASH partners can strongly influence how the nucleus functionally engages with different branches of the cytoskeleton.

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  • The osteoclast cytoskeleton is made of four categories of filamentous structures and fulfills essential functions including cell adhesion, migration, contractility, division, vesicular transport, and bone resorption.

    “The osteoclast cytoskeleton is made of filamentous structures that belong to one of four categories: polarized actin filaments; polarized microtubules; non-polarized intermediate filaments; or non-polarized septin filaments. The cytoskeleton fulfills essential functions including cell adhesion, migration, contractility, division, vesicular transport, and bone resorption [2,3,4,5,6].”

    From Osteoclasts and Microgravity (2020) · cites this paper as [6]

    The LINC diversity section discusses actin, microtubules, and intermediate filaments as cytoskeletal systems. It does not identify four categories, mention septin filaments, or establish the listed functions for osteoclasts, including bone resorption. Page numbers are not available in our copy. (LLM, conf=0.84)

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Authors
Burke, B.
Affiliations
Institute for Medical Biology (PL)
Corresponding author
Burke, Brian
ORCID
Burke, Brian
Venue
F1000Research
Publisher
F1000 Research Ltd
Published
2019-01-31
Volume
8
Pages
136
ISSN
2046-1402 (ISSN-L)
DOI
10.12688/f1000research.16877.1
PMC
PMC6357990
OpenAlex
W2912203822
Cited by
35
References
0
Citations by year
2026: 3 · 2025: 5 · 2024: 8 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 9 · 2019: 2
FWCI
0.35
Type
journal article
Language
en
Open access
Licence
Locations
  • F1000Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Medical Research Council, Singapore
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords
LINC complex, nuclear positioning, SUN proteins, KASH proteins, nuclear envelope, microtubule organizing center, nuclear migration, inner nuclear membrane, outer nuclear membrane, cellular architecture
MeSH terms
Animals, Cytoskeleton, Membrane Proteins, Nuclear Envelope, Nuclear Proteins, Nuclear Matrix

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