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Zeatin Supplement Improves Scopolamine-Induced Memory Impairment in Mice
Open accessAbstract
In this study, our aim was to clarify the ameliorative effects of zeatin, a development hormone in plants. Zeatin mitigated cognitive deficits and showed AChE inhibition in scopolamine (Scop)-induced mice following 21 d of zeatin treatment. After administration of Scop for 30 min, each mouse performed Y-maze and step-down latency tasks as a check on immediate against cognitive function. The results showed that zeatin administration attenuated Scop-induced memory damage and decreased AChE activity in the mice. This suggests that zeatin might be useful for protecting cognitive dysfunction, as well as for reducing the activation of AChE in dementia.
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trans-zeatin possesses an inhibitory effect on acetylcholinesterase.
“Some researchers found that trans-zeatin actually possesses an inhibitory effect on acetylcholinesterase and it can be used to treat Alzheimer’s disease or related neural dysfunctions, such as dementia [51,52].”
From The Chemical Composition and Biological Properties of Coconut (Cocos nucifera L.) Water (2009) · cites this paper as [52]
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Research works printed but not linked: 2
- 15) Julio, R., Haixia, D., Mengjuan, G., Ximmin, L., Shi-lin, C., and Gustavo, F. G., Aqueous and hydroalcholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice.Food Chem. Toxicol., in press.
- 21) Zavaleta-Mancera, H. A., López-Delgado, H., Loza-Tavera, H., Mora-Herrera, M., Trevilla-Gracia, C., Vagas-Suárez, M., and Helen, O., Cytokinin promotes catalase and ascorbate peroxidase activities and preserves the chloroplast integrity during dark-senescence.J. Plant Physiol., in press.
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The Chemical Composition and Biological Properties of Coconut (Cocos nucifera L.) Water
Yong, J. W. H., Ge, L., Ng, Y. F., & Tan, S. N. (2009) · Molecules · doi:10.3390/molecules14125144 · Cited by 753
“Some researchers found that trans-zeatin actually possesses an inhibitory effect on acetylcholinesterase and it can be used to treat Alzheimer’s disease or related neural dysfunctions, such as dementia [51,52].”
BackgroundComposition, Properties and Reactions of Coconut Water
Rethinam, P., & Krishnakumar, V. (2022) · Coconut Water · doi:10.1007/978-3-031-10713-9_4 · Cited by 9
Metadata
- Authors
- KIM, M. J., CHOI, S. J., LIM, S.-T., KIM, H. K., KIM, Y. J., YOON, H.-G., & SHIN, D.-H.
- Affiliations
- Yonsei University (KR)
- Korea University (KR)
- Hanseo University (KR)
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-02-23
- Volume
- 72
- Issue
- 2
- Pages
- 577-581
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2078041094
- Cited by
- 47
- References
- 0
- Citations by year
- 2024: 4 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 4 · 2012: 7
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Rural Development Administration
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- zeatin, scopolamine, memory impairment, acetylcholinesterase inhibition, cognitive impairment, dementia, neuroprotection, Y-maze
- MeSH terms
- Animals, Memory Disorders, Scopolamine, Zeatin, Cholinergic Antagonists, Mice
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