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Isolation and Characterization of E–64, a New Thiol Protease Inhibitor
Open accessAbstract
A new thiol protease inhibitor, named E-64, was isolated from the extract of a solid culture of Aspergillus japonicus TPR-64 freshly isolated from soil.E-64 was obtained as white needles and the empirical formula was estimated to be C15N5-H27O5 (M.W. 357).This was almost neutral in its electrophoretic behavior and proved to be a specific and strong inhibitor toward thiol protease such as papain and cathepsin B. They combine equimolecularly and irreversibly.
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Cited by
Cysteine cathepsins: From structure, function and regulation to new frontiers
Turk, V., Stoka, V., Vasiljeva, O., Renko, M., Sun, T., Turk, B., & Turk, D. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.10.002 · Cited by 1,377
Calpain: A Protease in Search of a Function?
Carafoli, E., & Molinari, M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8378 · Cited by 355
Metadata
- Authors
- Hanada, K., Tamai, M., Yamagishi, M., Ohmura, S., Sawada, J., & Tanaka, I.
- Venue
- Agricultural and Biological Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1978-03
- Volume
- 42
- Issue
- 3
- Pages
- 523-528
- ISSN
- 0002-1369 (ISSN-L)
- OpenAlex
- W2034296548
- Cited by
- 365
- References
- 0
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Isolation and Characterization of E–64, a New Thiol Protease Inhibitor. https://app.cochat.ai/papers/10.1080/00021369.1978.10863014
- The paper
- Hanada, K., Tamai, M., Yamagishi, M., Ohmura, S., Sawada, J., & Tanaka, I. (1978). Isolation and Characterization of E–64, a New Thiol Protease Inhibitor. Agricultural and Biological Chemistry. https://doi.org/10.1080/00021369.1978.10863014
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
