Disposition of orally administered 2,2-Bis(4-hydroxyphenyl)propane (Bisphenol A) in pregnant rats and the placental transfer to fetuses.
Open accessAbstract
We studied the disposition of bisphenol A (BPA) in pregnant female F344/DuCrj(Fischer) rats and its placental transfer to fetuses after a single oral administration of 1 g/kg BPA dissolved in propylene glycol. BPA in maternal blood, liver, and kidney reached maximal concentrations (14.7, 171, and 36 microg/g) 20 min after the administration and gradually decreased. The levels were 2-5% of the maximum 6 hr after the administration. The maximal concentration of BPA in fetuses (9 microg/g) was also attained 20 min after the administration. BPA levels then gradually reduced in a similar manner to maternal blood. These results suggest that the absorption and distribution of BPA in maternal organs and fetuses are extremely rapid and that the placenta does not act as a barrier to BPA.
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BPA can traverse the placenta and reach the fetus in humans and other species.
“There is evidence that BPA can traverse the placenta and reach the fetus in humans and other species [107, 108].”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [108]
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References 35 · Cited by 240
- Authors
- Takahashi, O., & Oishi, S.
- Affiliations
- Tokyo Metropolitan Institute of Public Health (JP)
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-10-01
- Volume
- 108
- Issue
- 10
- Pages
- 931-935
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC1240124
- OpenAlex
- W2114926342
- Cited by
- 240
- References
- 35
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 14 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 12 · 2015: 8 · 2014: 10 · 2013: 9 · 2012: 12
- FWCI
- 7.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/licenses/by/4.0/ (vor, 6298 d)
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- bisphenol A, placental transfer, prenatal exposure, maternal-fetal transfer, pharmacokinetics, oral administration, pregnancy, placental barrier, tissue distribution, F344 rats
- MeSH terms
- Absorption, Bisphenol A Compounds, Administration, Oral, Air Pollutants, Occupational, Animals, Benzhydryl Compounds, Female, Maternal-Fetal Exchange, Phenols, Placenta, Pregnancy, Rats, Inbred F344, Time Factors, Tissue Distribution, Rats
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