The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary.
Open accessAbstract
Fetuses, infants, and juveniles (preadults) should not be considered simply "small adults" when it comes to toxicological risk. We present specific examples of developmental toxicants that are more toxic to children than to adults, focusing on effects on the immune and respiratory systems. We describe differences in both the pharmacokinetics of the developing immune and respiratory systems as well as changes in target organ sensitivities to toxicants. Differential windows of vulnerability during development are identified in the context of available animal models. We provide specific approaches to directly investigate differential windows of vulnerability. These approaches are based on fundamental developmental biology and the existence of discrete developmental processes within the immune and respiratory systems. The processes are likely to influence differential developmental susceptibility to toxicants, resulting in lifelong toxicological changes. We also provide a template for comparative research. Finally, we discuss the application of these data to risk assessment.
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Citations
Cites
Parental smoking and respiratory illness in infancy
Fergusson, D. M., Horwood, L. J., & Shannon, F. T. (1980) · Archives of Disease in Childhood · doi:10.1136/adc.55.5.358 · Cited by 145
Cited by
The effect of pollution on labor supply: Evidence from a natural experiment in Mexico City
Hanna, R., & Oliva, P. (2015) · Journal of Public Economics · doi:10.1016/j.jpubeco.2014.10.004 · Cited by 704
Identifying critical windows of exposure for children's health.
Selevan, S. G., Kimmel, C. A., & Mendola, P. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3451 · Cited by 559
The role of air pollution in asthma and other pediatric morbidities
Trasande, L., & Thurston, G. D. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.01.056 · Cited by 359
Schneider, T., Roman, A., Basta-Kaim, A., Kubera, M., Budziszewska, B., Schneider, K., & Przewłocki, R. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.02.011 · Cited by 337
Leon Hsu, H.-H., Mathilda Chiu, Y.-H., Coull, B. A., Kloog, I., Schwartz, J., Lee, A., Wright, R. O., & Wright, R. J. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201504-0658oc · Cited by 315
Metadata
- Authors
- Dietert, R. R., Etzel, R. A., Chen, D., Halonen, M., Holladay, S. D., Jarabek, A. M., Landreth, K., Peden, D. B., Pinkerton, K., Smialowicz, R. J., & Zoetis, T.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-06
- Volume
- 108
- Issue
- suppl 3
- Pages
- 483-490
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2048942183
- Cited by
- 315
- References
- 1
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Dietert, R. R., Etzel, R. A., Chen, D., Halonen, M., Holladay, S. D., Jarabek, A. M., Landreth, K., Peden, D. B., Pinkerton, K., Smialowicz, R. J., & Zoetis, T. (2000). Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary. Environmental Health Perspectives. https://doi.org/10.1289/ehp.00108s3483
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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