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Chronic Fine and Coarse Particulate Exposure, Mortality, and Coronary Heart Disease in the Nurses’ Health Study
Open accessAbstract
BACKGROUND: The relationship of fine particulate matter < 2.5 microm in diameter (PM(2.5)) air pollution with mortality and cardiovascular disease is well established, with more recent long-term studies reporting larger effect sizes than earlier long-term studies. Some studies have suggested the coarse fraction, particles between 2.5 and 10 microm (PM(10-2.5)), may also be important. With respect to mortality and cardiovascular events, questions remain regarding the relative strength of effect sizes for chronic exposure to fine and coarse particles. OBJECTIVES: We examined the relationship of chronic PM(2.5) and PM(10-2.5) exposures with all-cause mortality and fatal and nonfatal incident coronary heart disease (CHD), adjusting for time-varying covariates. METHODS: The current study included women from the Nurses' Health Study living in metropolitan areas of the northeastern and midwestern United States. Follow-up was from 1992 to 2002. We used geographic information systems-based spatial smoothing models to estimate monthly exposures at each participant's residence. RESULTS: We found increased risk of all-cause mortality [hazard ratio (HR), 1.26; 95% confidence interval (CI), 1.02-1.54] and fatal CHD (HR = 2.02; 95% CI, 1.07-3.78) associated with each 10-microg/m(3) increase in annual PM(2.5) exposure. The association between fatal CHD and PM(10-2.5) was weaker. CONCLUSIONS: Our findings contribute to growing evidence that chronic PM(2.5) exposure is associated with risk of all-cause and cardiovascular mortality.
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Cited by
Lim, S. S., Vos, T., Flaxman, A. D., Danaei, G., Shibuya, K., Adair-Rohani, H., AlMazroa, M. A., Amann, M., Anderson, H. R., Andrews, K. G., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61766-8 · Cited by 11,805
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Self-citationAnenberg, S. C., Schwartz, J., Shindell, D., Amann, M., Faluvegi, G., Klimont, Z., Janssens-Maenhout, G., Pozzoli, L., Van Dingenen, R., Vignati, E., et al. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104301 · Cited by 442
Self-citation
Metadata
- Authors
- Puett, R. C., Hart, J. E., Yanosky, J. D., Paciorek, C., Schwartz, J., Suh, H., Speizer, F. E., & Laden, F.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-11
- Volume
- 117
- Issue
- 11
- Pages
- 1697-1701
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W1964829247
- Cited by
- 368
- References
- 5
- FWCI
- 14.76
- Type
- journal article
- Language
- en
- Open access
- gold
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