Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease
Gao, Hui-Ming, Zhang, Feng, Zhou, Hui, Kam, Wayneho, Wilson, Belinda, Hong, Jau-Shyong·2011·Environmental Health Perspectives
Cited by (355)
Items 301–355 of 355
- Understanding the Pre-Clinical Stages of Parkinson’s Disease: Where Are We in Clinical and Research Settings?Camilla Dalla Verde, Sri Delasmi Jayanti, Korri Elvanita El-Khobar, John A. Stanford, Claudio Tiribelli, Silvia Gazzin · 2025 · International Journal of Molecular Sciences
- Neuronal titration of Snca via enhancer disruption mitigates disease onset in a Parkinson's disease mouse modelRachel J. Boyd, A Ra Kho, Sarah A. McClymont, Stacie K. Loftus, Han Seok Ko, Andrew S. McCallion · 2026 · Brain
- Potential role of splice junctions of α-synuclein isoforms in the activation of T-cells: Implications for Parkinson's diseaseShweta Kaul, Aravind Vulli, Shasi V. Kalivendi · 2026 · Cellular Signalling
- Mechanisms of neurotoxicity of fluoride or aluminum: implications for neurodegenerative disease riskZhi-Lin Wang, Tracie R. Baker, Ashley J. Malin · 2026 · Current Research in Toxicology
- The role of environmental toxins and inflammation in Parkinson's disease pathophysiology: a historical perspective and research-based evidenceFrancisco J. Pan-Montojo, Kai F. Loewenbrück, Heinz Reichmann · 2020 · Elsevier eBooks
- The Effect of Systemic Inflammation on Cognitive Function and Neurodegenerative DiseaseColm M. Cunningham, Donal Skelly · 2021 · Cambridge University Press eBooks
- NEUROINFLAMMATION AND IMMUNE DYSFUNCTION IN THE PATHOGENESIS OF PARKINSON’S DISEASEGalina V. Idova, Альперина Елизавета Лазаревна, Svetlana Ya. Zhanaeva · 2023 · Журнал высшей нервной деятельности им И П Павлова
- Neuroinflammation, glymphatic system, and Parkinson's diseaseSohaila Mohammed Salah Saleh, Nada Nasser, Engy K. Tharwat, Tasneem Elbehiry, Hagar Ismail Helmy · 2024 · Elsevier eBooks
- Putative neuroprotective compounds in in vitro models of dopaminergic neurodegenerationBernardino Ossola · 2011 · Työväentutkimus Vuosikirja
- "A GREAT PERTURBATION IN NATURE" : PARKINSON'S DISEASE AND SLEEP DISORDERSAri Ylikoski · 2016 · Työväentutkimus Vuosikirja
- Modelling Parkinson’s Disease Pre-Clinically: A Novel Virus-Fibril Inducible Mouse Model Exploring Disease Characteristics and Therapeutic Intervention via Metabotropic Glutamate Receptor 5 Negative Allosteric ModulationSamantha C. Bureau · 2022 · Carleton University's Institutional Repository (MacOdrum Library, Carleton University)
- The Role of Neutral Sphingolipids in the Pathogenesis of Parkinson Disease and Dementia with Lewy BodiesSingh, Priyanka · 2013 · uO Research (University of Ottawa)
- Considerations on the role of environmental toxins in idiopathic Parkinson's diseaseFrancisco J. Pan-Montojo, Heinz Reichmann · 2014
- Aging and Microglial Activation in Neurodegenerative DiseasesEsteban A. Oyarzabal, Yen‐Yu Ian Shih, Jau‐Shyong Hong · 2016 · Oxidative stress in applied basic research and clinical practice
- Inflammation-Mediated Neurodegeneration: Models, Mechanisms, and Therapeutic Interventions for Neurodegenerative DiseasesHui‐Ming Gao, Yun Gao, Dezhen Tu, Yue Liu, Hui Zhou, Jau‐Shyong Hong · 2017 · Wiley-VCH eBooks
- Cognitive Movement Disorders, Gut Dysbiosis and Skin DiseasesChan Kam Tim Michael · 2018 · Biomedical Journal of Scientific & Technical Research
- The Impact of Methylenetetrahydrofolate Reductase (MTHFR) Deficiency in a Paraquat Mouse Model of Parkinson’s DiseaseLauren Murray · 2018
- Alpha-synuclein spreading pathology in Parkinson's disease: the influence of iron and the Rho-kinase inhibitor fasudilKarina Joppe · 2020 · eDiss (Georg-August-Universität Göttingen)
- Divergence in Neuronal Calcium Dysregulation in Brain Aging and Animal Models of ADAdam O. Ghoweri · 2020 · UKnowledge (University of Kentucky)
- Gut Microbiota in Brain diseasesMahmoud Salami · 2021 · Elsevier eBooks
- Resveratrol and brain mitochondriaPatrícia Coelho, Ana Cristina Rego · 2021 · Elsevier eBooks
- Role of caspases and apoptosis in Parkinson's diseaseAnil Gupta · 2021 · Elsevier eBooks
- Disturbances in Redox Homeostasis in the Ageing BrainSambe Asha Devi, T. B. Basavaraju · 2021 · Healthy ageing and longevity
- Efficacy of Phytochemicals and Natural Products in the Management/Treatment of Neurodegenerative DiseasesJohnson Olaleye Oladele, Oluwaseun Titilope Oladele, Taiwo Scholes Adewole, Oyedotun M. Oyeleke, Adenike Temidayo Oladiji · 2022 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
- LRRK2-G2019S Synergizes With Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation That Precede Nigrostriatal DegenerationBianca Marchetti, Carmela Giachino, Cataldo Tirolo, Salvatore Caniglia, Maria Francesca Serapide, Francesca L’Episcopo, Federico Bertoli, Claudio Giuliano, Marika Mearelli, Meike Jakobi et al. · 2022 · Research Square
- Novel Theranostics for Parkinson's DiseaseBenjamin William Schlichtmann · 2021
- Effects of acupuncture on Parkinson's disease-related constipation and roles of gut microbial ecology: study protocol for a randomized controlled clinical trialSuying Lei, Jingqi Fan, Jingyi Quan, Yinjia Li, Minjun Cen, Xiaoyan Xu, Xin Liu, Shunan Wu, Kaihao Liao, Shumin Lin et al. · 2024 · Research Square
- Role of the Gut Microbiome and Bacterial Amyloids in the Development of Synucleinopathies (Review)Nina P. Trubitsina, Anton B. Matiiv, Tatyana M. Rogoza, Anna A. Zudilova, Mariya D. Bezgina, Galina A. Zhouravleva, Stanislav A. Bondarev · 2024 · Biochemistry (Moscow)
- In vivo and in silico alpha-synuclein propagation dynamics: The role of genotype, epicentre, and connectivityStéphanie Tullo, Janice Park, Shady Rahayel, Daniel Gallino, Megan Park, Kristie Mar, Ying‐Qiu Zheng, Esther del Cid‐Pellitero, Edward A. Fon, Wen Luo et al. · 2025 · eLife
- The compounding roles of gut-immune-brain axis and COVID19 in manifestation of idiopathic Parkinson’s diseaseAnkita Das, Vani Vivek, Palok Aich · 2025 · Discover Immunity.
- Reduced levels of nitrated α-synuclein in the protective effect of harpagoside on rotenone-induced cellular models of Parkinson’s diseaseJuan Lang, Zhongkui Xiong · 2025 · Frontiers in Cell and Developmental Biology
- From Kitchen Spice to Neuroprotector: The Role of 6-Shogaol in Parkinson’s Disease ManagementJiahui Jin, Xiran Li, Yunxi Wang, Zishu Yan, Airong Lv, Yanjun Zhang, Pengwei Zhuang, Hong Guo · 2025 · Journal of Agricultural and Food Chemistry
- Advanced age and lipopolysaccharide influence behavioral and neurodegenerative features in LRRK2 G2019S knock-in miceAnuroopa Dinesh, Teresa Fortin, Hongyu Sun, Shawn P. Hayley · 2025 · Behavioural Brain Research
- Additional file 13 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El‐Agnaf, Abid Oueslati · 2024 · Figshare
- Additional file 8 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El‐Agnaf, Abid Oueslati · 2024 · Figshare
- Additional file 9 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El‐Agnaf, Abid Oueslati · 2024 · Figshare
- Additional file 7 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El‐Agnaf, Abid Oueslati · 2024 · Figshare
- Additional file 1 of Differential seeding and propagating efficiency of α-synuclein strains generated in different conditionsDi Liu, Guo, Jian-Jun, Su, Ji-Hui, Alexander Svanbergsson, Yuan, Lin, Caroline Haikal, Li, Wen, Gunnar K. Gouras, Jiayi Li · 2021 · Figshare
- Additional file 5 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El‐Agnaf, Abid Oueslati · 2024 · Figshare
- Additional file 1 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El‐Agnaf, Abid Oueslati · 2023 · Figshare
- Additional file 3 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El‐Agnaf, Abid Oueslati · 2024 · Figshare
- Additional file 6 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El‐Agnaf, Abid Oueslati · 2024 · Figshare
- Additional file 2 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El‐Agnaf, Abid Oueslati · 2024 · Figshare
- Additional file 11 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, El-Agnaf, Omar M. A., Abid Oueslati · 2024 · Figshare
- Additional file 4 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El‐Agnaf, Abid Oueslati · 2024 · Figshare
- Additional file 12 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El‐Agnaf, Abid Oueslati · 2024 · Figshare
- Additional file 10 of Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brainsMorgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El‐Agnaf, Abid Oueslati · 2024 · Figshare
- Air pollution and neurotoxicity: The role of environmental pollutants in movement disordersKimberly C. Paul, Jeff M. Bronstein · 2026 · International review of movement disorders
- Étude moléculaire de la propagation de l’agrégation de l’alpha-synucléine dans un modèle transgénique de la maladie de Parkinson : impact de la surexpression de la beta-synucléine à l’aide de vecteurs viraux adéno-associés (AAV)Dorian Sargent · 2018 · theses.fr (ABES)
- Dietary restriction as a potential neuroprotective intervention: a narrative review of its impact on neuroinflammation across neurodegenerative diseases and other neurological disordersBuhui Liu, Yating Zhang, Wenxin Deng, Yi Zhou, Yuhan Cao, Lie Xiong, Ruoyi Shen, Simon Ming-Yuen Lee, Jinsong Bian, Yaqi Bian · 2026 · Frontiers in Nutrition
- GLP-1 analogs restore inflammatory, mitochondrial and intercellular signaling networks in the Snca G51D/G51D knock-in mouse model of Parkinson’s diseaseBhupesh Vaidya, Yan Li, Young Doo Kim, Cameron Osterman, Jean‐Pierre Revelli, Huda Yahya Zoghbi · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Astrocytic Redox Homeostasis as a Metabolic Modulator of DNA Damage and Repair in the Ischemic PenumbraRenata Kołodziejska, Antoni Godlewski, Agnieszka Tafelska‐Kaczmarek, Julia Kuk, Magdalena Moritz, Krzysztof Sergot, Natalia Kurhaluk, Галина Михайлівна Ткаченко, Alina Woźniak · 2026 · Cells
- Serum miR-423–5p discriminates patients with Parkinson's disease from healthy individuals and is associated with severity and the risk of cognitive dysfunctionPingting Chen, Wei Wang, Hengping Chen, Fang Ye · 2026 · Clinical Neurology and Neurosurgery
- Zebrafish models provide insight into the biological classification of Parkinson's diseaseWael Mohamed, Tiago F. Outeiro · 2026 · Elsevier eBooks
- Spatiotemporal Changes in the Cytokine Profile in the Brain of A53T Transgenic Mice, a Model of Parkinson’s DiseaseАльперина Елизавета Лазаревна, Galina V. Idova, Svetlana Ya. Zhanaeva, Maria A. Tikhonova, Margarita M. Gevorgyan, Lyubomir I. Aftanas · 2026 · Biochemistry (Moscow)