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Ambient Air Pollution and Preeclampsia: A Spatiotemporal Analysis
Open accessAbstract
Background: Available evidence concerning the association between air pollution and preeclampsia is limited, and specific associations with early- and late-onset preeclampsia have not been assessed. Objectives: We investigated the association, if any, between preeclampsia (all, early-, and late-onset) and exposure to nitrogen dioxide, nitrogen oxides, particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5; fine particles), ≤ 10 μm, and 2.5–10 μm, and PM2.5 light absorption (a proxy for elemental carbon) during the entire pregnancy and during the first, second, and third trimesters. Methods: This study was based on 8,398 pregnancies (including 103 cases of preeclampsia) among women residing in Barcelona, Spain (2000–2005). We applied a spatiotemporal exposure assessment framework using land use regression models to predict ambient pollutant levels during each week of pregnancy at the geocoded residence address of each woman at the time of birth. Logistic and conditional logistic regression models were used to estimate unadjusted and adjusted associations. Results: We found positive associations for most of our evaluated outcome–exposure pairs, with the strongest associations observed for preeclampsia and late-onset preeclampsia in relation to the third-trimester exposure to fine particulate pollutants, and for early-onset preeclampsia in relation to the first-trimester exposure to fine particulate pollutants. Among our investigated associations, those of first- and third-trimester exposures to PM2.5 and third-trimester exposure to PM2.5 absorbance and all preeclampsia, and third-trimester PM2.5 exposure and late-onset preeclampsia attained statistical significance. Conclusion: We observed increased risk of preeclampsia associated with exposure to fine particulate air pollution. Our findings, in combination with previous evidence suggesting distinct pathogenic mechanisms for early- and late-onset preeclampsia, support additional research on this topic. Citation: Dadvand P, Figueras F, Basagaña X, Beelen R, Martinez D, Cirach M, Schembari A, Hoek G, Brunekreef B, Nieuwenhuijsen MJ. 2013. Ambient air pollution and preeclampsia: a spatiotemporal analysis. Environ Health Perspect 121:1365–1371; http://dx.doi.org/10.1289/ehp.1206430
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“Recently, some studies have discussed the possible association between air pollution and HDP [27, 28].”
From Epidemiological trends of maternal hypertensive disorders of pregnancy at the global, regional, and national levels: a population‐based study (2021) · cites this paper as [27]
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Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181dbece1 · Cited by 6,548
No adjustments are needed for multiple comparisons.
Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
Brown, M. A., Lindheimer, M. D., de Swiet, M., Assche, A. V., & Moutquin, J. (2001) · Hypertension in Pregnancy · doi:10.1081/prg-100104165 · Cited by 1,894
Sibai, B. M., Dekker, G., & Kupferminc, M. J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17987-2 · Cited by 1,852
A review of land-use regression models to assess spatial variation of outdoor air pollution
Hoek, G., Beelen, R. M. J., de Hoogh, K., Vienneau, D., Gulliver, J., Fischer, P. H., & Briggs, D. J. (2008) · Atmospheric Environment · doi:10.1016/j.atmosenv.2008.05.057 · Cited by 1,465
Self-citationBrown, M. A., Lindheimer, M. D., de SWIET, M., et al. (2001) · Hypertension in Pregnancy · doi:10.3109/10641950109152635 · Cited by 1,369
Do multiple outcome measures require p-value adjustment?
Feise, R. J. (2002) · BMC Medical Research Methodology · doi:10.1186/1471-2288-2-8 · Cited by 1,299
Eeftens, M., Beelen, R., de Hoogh, K., Bellander, T., Cesaroni, G., Cirach, M., Declercq, C., Dėdelė, A., Dons, E., de Nazelle, A., et al. (2012) · Environmental Science & Technology · doi:10.1021/es301948k · Cited by 1,214
Self-citationSibai, B. M., Dekker, G. A., & Kupferminc, M. J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71003-5 · Cited by 1,089
Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy
Hutcheon, J. A., Lisonkova, S., & Joseph, K. S. (2011) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2011.01.006 · Cited by 1,056
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Metadata
- Authors
- Dadvand, P., Figueras, F., Basagaña, X., Beelen, R., Martinez, D., Cirach, M., Schembari, A., Hoek, G., Brunekreef, B., & Nieuwenhuijsen, M. J.
- Affiliations
- Center for Research in Environmental Epidemiology (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Utrecht University (NL)
- Corresponding author
- Dadvand, Payam
- ORCID
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-01-01
- Volume
- 121
- Issue
- 11-12
- Pages
- 1365-1371
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC3855505
- OpenAlex
- W2055280773
- Cited by
- 145
- References
- 48
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 10 · 2023: 7 · 2022: 15 · 2021: 23 · 2020: 17 · 2019: 8 · 2018: 12 · 2017: 5 · 2016: 5 · 2015: 12 · 2014: 14
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/licenses/by/4.0/ (vor, 1823 d)
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Funders
- European Commission (211250)
- Ministerio de Ciencia e Innovación (JCI-2011-09937)
- Instituto de Salud Carlos III
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
- Keywords
- preeclampsia, ambient air pollution, PM2.5, elemental carbon, nitrogen dioxide, nitrogen oxides, early-onset preeclampsia, late-onset preeclampsia, trimester-specific exposure, pregnancy, land use regression, Barcelona
- MeSH terms
- Adult, Age Factors, Air Pollution, Cities, Educational Status, Environmental Exposure, Female, Humans, Nitrogen Oxides, Particle Size, Pre-Eclampsia, Pregnancy, Regression Analysis, Risk Factors, Smoking, Socioeconomic Factors, Spain, Time Factors, Body Mass Index, Odds Ratio, Statistics, Nonparametric, Particulate Matter
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