Cited by 364Asthma and respiratory diseasesAir Quality and Health ImpactsIndoor Air Quality and Microbial Exposure
How Exposure to Environmental Tobacco Smoke, Outdoor Air Pollutants, and Increased Pollen Burdens Influences the Incidence of Asthma
Open accessGilmour, M. Ian, Jaakkola, Maritta S., London, Stephanie J., Nel, Andre E., Rogers, Christine A.·2006·Environmental Health Perspectives
DOI 10.1289/ehp.8380PMC PMC1440792
Abstract
Asthma is a multifactorial airway disease that arises from a relatively common genetic background interphased with exposures to allergens and airborne irritants. The rapid rise in asthma over the past three decades in Western societies has been attributed to numerous diverse factors, including increased awareness of the disease, altered lifestyle and activity patterns, and ill-defined changes in environmental exposures. It is well accepted that persons with asthma are more sensitive than persons without asthma to air pollutants such as cigarette smoke, traffic emissions, and photochemical smog components. It has also been demonstrated that exposure to a mix of allergens and irritants can at times promote the development phase (induction) of the disease. Experimental evidence suggests that complex organic molecules from diesel exhaust may act as allergic adjuvants through the production of oxidative stress in airway cells. It also seems that climate change is increasing the abundance of aeroallergens such as pollen, which may result in greater incidence or severity of allergic diseases. In this review we illustrate how environmental tobacco smoke, outdoor air pollution, and climate change may act as environmental risk factors for the development of asthma and provide mechanistic explanations for how some of these effects can occur.
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PM-mediated oxidative stress can induce inflammation, sometimes referred to as the tier 2 response preceding tier 3 cytotoxicity or cell death.
“Alternatively, PM-mediated oxidative stress can induce inflammation, sometimes referred to as the tier 2 response preceding tier 3 cytotoxicity or cell death [149, 150].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [150]
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- Authors
- Gilmour, M. I., Jaakkola, M. S., London, S. J., Nel, A. E., & Rogers, C. A.
- Affiliations
- Environmental Protection Agency (US)
- University of Birmingham (GB)
- National Institute of Environmental Health Sciences (US)
- Department of Medicine, University of California Los Angeles, Los Angeles, California, USA
- Harvard University (US)
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-01-26
- Volume
- 114
- Issue
- 4
- Pages
- 627-633
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC1440792
- OpenAlex
- W2109865874
- Cited by
- 364
- References
- 75
- Citations by year
- 2025: 6 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 21 · 2020: 13 · 2019: 17 · 2018: 12 · 2017: 16 · 2016: 17 · 2015: 18 · 2014: 16 · 2013: 22 · 2012: 32
- FWCI
- 20.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/licenses/by/4.0/ (vor, 4355 d)
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- asthma incidence, environmental tobacco smoke, outdoor air pollution, pollen exposure, climate change, aeroallergens, diesel exhaust, oxidative stress, airway irritants, vehicle emissions, photochemical smog, asthma risk factors, disease induction
- MeSH terms
- Air Pollutants, Asthma, Environmental Exposure, Humans, Pollen, Smoke, Nicotiana, Incidence, Greenhouse Effect
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