The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
p-Nonyl-phenol: an estrogenic xenobiotic released from "modified" polystyrene.
Open accessAbstract
Alkylphenols are widely used as plastic additives and surfactants. We report the identification of an alkylphenol, nonylphenol, as an estrogenic substance released from plastic centrifuge tubes. This compound was extracted with methanol, purified by flash chromatography and reverse-phase high performance liquid chromatography, and identified by gas chromatography-mass spectrometry. Nonylphenol induced both cell proliferation and progesterone receptor in human estrogen-sensitive MCF7 breast tumor cells. Nonylphenol also triggered mitotic activity in rat endometrium; this result confirms the reliability of the MCF7 cell proliferation bioassay. The estrogenic properties of alkylphenols, specifically nonylphenols, indicate that the use of plasticware containing these chemicals in experimental and diagnostic tests may lead to spurious results, and these compounds as well as alkylphenol polyethoxylates may also be potentially harmful to exposed humans and the environment at large.
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Berthois, Y., Katzenellenbogen, J. A., & Katzenellenbogen, B. S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2496 · Cited by 1,307
Cited by
Endocrine Disruptors: From Endocrine to Metabolic Disruption
Casals-Casas, C., & Desvergne, B. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142200 · Cited by 902
The estrogenic activity of phthalate esters in vitro.
Harris, C. A., Henttu, P., Parker, M. G., & Sumpter, J. P. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105802 · Cited by 835
Blair, R. M. (2000) · Toxicological Sciences · doi:10.1093/toxsci/54.1.138 · Cited by 806
Some Alkyl Hydroxy Benzoate Preservatives (Parabens) Are Estrogenic
Routledge, E. J., Parker, J., Odum, J., Ashby, J., & Sumpter, J. P. (1998) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8544 · Cited by 721
Environmental Signaling: What Embryos and Evolution Teach Us About Endocrine Disrupting Chemicals
McLachlan, J. A. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.3.0432 · Cited by 608
Metadata
- Authors
- Soto, A. M., Justicia, H., Wray, J. W., & Sonnenschein, C.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1991-05
- Volume
- 92
- Pages
- 167-173
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2061947638
- Cited by
- 1,082
- References
- 1
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: p-Nonyl-phenol: an estrogenic xenobiotic released from "modified" polystyrene. https://app.cochat.ai/papers/10.1289/ehp.9192167
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- Soto, A. M., Justicia, H., Wray, J. W., & Sonnenschein, C. (1991). p-Nonyl-phenol: an estrogenic xenobiotic released from "modified" polystyrene. Environmental Health Perspectives. https://doi.org/10.1289/ehp.9192167
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
