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Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop.
Open accessAbstract
The hypothesis has been put forward that humans and wildlife species adverse suffered adverse health effects after exposure to endocrine-disrupting chemicals. Reported adverse effects include declines in populations, increases in cancers, and reduced reproductive function. The U.S. Environmental Protection Agency sponsored a workshop in April 1995 to bring together interested parties in an effort to identify research gaps related to this hypothesis and to establish priorities for future research activities. Approximately 90 invited participants were organized into work groups developed around the principal reported health effects-carcinogenesis, reproductive toxicity, neurotoxicity, and immunotoxicity-as well as along the risk assessment paradigm-hazard identification, dose-response assessment, exposure assessment, and risk characterization. Attention focused on both ecological and human health effects. In general, group felt that the hypothesis warranted a concerted research effort to evaluate its validity and that research should focus primarily on effects on development of reproductive capability, on improved exposure assessment, and on the effects of mixtures. This report summarizes the discussions of the work groups and details the recommendations for additional research.
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Total serum testosterone and gonadotropins in workers exposed to dioxin
Egeland, G. M., Sweeney, M. H., Fingerhut, M. A., Wille, K. K., Schnorr, T. M., & Halperin, W. E. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116994 · Cited by 120
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Metabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101
Esplugas, S., Bila, D. M., Krause, L. G. T., & Dezotti, M. (2007) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2007.07.073 · Cited by 1,020
A review on endocrine disruptors and their possible impacts on human health
Kabir, E. R., Rahman, M. S., & Rahman, I. (2015) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2015.06.009 · Cited by 945
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Wetherill, Y. B., Akingbemi, B. T., Kanno, J., McLachlan, J. A., Nadal, A., Sonnenschein, C., Watson, C. S., Zoeller, R. T., & Belcher, S. M. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.05.010 · Cited by 920
Metadata
- Authors
- Kavlock, R. J., Daston, G. P., DeRosa, C., Fenner-Crisp, P., Gray, L. E., Kaattari, S., Lucier, G., Luster, M., Mac, M. J., Maczka, C., Miller, R., Moore, J., Rolland, R., Scott, G., Sheehan, D. M., Sinks, T., & Tilson, H. A.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-08
- Volume
- 104
- Issue
- suppl 4
- Pages
- 715-740
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W1988609641
- Cited by
- 1,149
- References
- 4
- FWCI
- 42.01
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop. https://app.cochat.ai/papers/10.1289/ehp.96104s4715
- The paper
- Kavlock, R. J., Daston, G. P., DeRosa, C., Fenner-Crisp, P., Gray, L. E., Kaattari, S., Lucier, G., Luster, M., Mac, M. J., Maczka, C., Miller, R., Moore, J., Rolland, R., Scott, G., Sheehan, D. M., Sinks, T., & Tilson, H. A. (1996). Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop. Environmental Health Perspectives. https://doi.org/10.1289/ehp.96104s4715
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
