The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Free radical activity of PM10: iron-mediated generation of hydroxyl radicals.
Open accessAbstract
The purpose of this study was to test the hypothesis that particulate matter < or = 10 microns in aerodynamic diameter (PM10) particles have the ability to generate free radical activity at their surface. We collected PM10 filters from the Edinburgh, United Kingdom, Enhanced Urban Network sampling site, removed particles from the filter, and tested their ability to cause free radical damage to supercoiled plasmid DNA. We found that the PM10 particles did cause damage to the DNA that was mediated by hydroxyl radicals, as shown by inhibition of the injury with mannitol. The PM10-associated hydroxyl radical activity was confirmed using a high-performance liquid chromatography-based assay to measure the hydroxyl radical adduct of salicylic acid. Desferrioxamine abolished the hydroxyl radical-mediated injury, which suggests that iron was involved. Analysis of PM10 filters confirmed the presence of large amounts of iron and leaching studies confirmed that the PM10 samples could release substantial amounts of Fe(III) and lesser amounts of Fe(II). To investigate the size of the particles involved in the hydroxyl radical injury, we centrifuged the suspension of PM10 to clarity, tested the clear supernatant, and found that it had all of the suspension activity. We conclude, therefore, that the free radical activity is derived either from a fraction that is not centrifugeable on a bench centrifuge, or that the radical generating system is released into solution.
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Citations
Cites
Systemic oxidative stress in asthma, COPD, and smokers
Rahman, I., Morrison, D., Donaldson, K., & MacNee, W. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.4.8887607 · Cited by 774
Free Radical Generation at the Solid/Liquid Interface in Iron Containing Minerals
Fubini, B., Mollo, L., & Giamello, E. (1995) · Free Radical Research · doi:10.3109/10715769509065280 · Cited by 177
Cited by
Brook, R. D., Franklin, B., Cascio, W., Hong, Y., Howard, G., Lipsett, M., Luepker, R., Mittleman, M., Samet, J., Smith, S. C., et al. (2004) · Circulation · doi:10.1161/01.cir.0000128587.30041.c8 · Cited by 2,380
Oxidative stress-induced DNA damage by particulate air pollution
Risom, L., Møller, P., & Loft, S. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2005.06.012 · Cited by 913
Valavanidis, A., Vlachogianni, T., Fiotakis, K., & Loridas, S. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10093886 · Cited by 910
Role of Free Radicals in the Toxicity of Airborne Fine Particulate Matter
Dellinger, B., Pryor, W. A., Cueto, R., Squadrito, G. L., Hegde, V., & Deutsch, W. A. (2001) · Chemical Research in Toxicology · doi:10.1021/tx010050x · Cited by 532
Valavanidis, A., Vlachogianni, T., & Fiotakis, K. (2009) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph6020445 · Cited by 519
“The significance of the generation of HO (through the reactions of cigarette tar and other ambient respirable particles) for carcinogenicity and DNA damage due to their highly reactive and oxidizing nature has been emphasized by many research groups [70, 71].”
Background
Metadata
- Authors
- Donaldson, K., Brown, D. M., Mitchell, C., Dineva, M., Beswick, P. H., Gilmour, P., & MacNee, W.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-09
- Volume
- 105
- Issue
- suppl 5
- Pages
- 1285-1289
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W1964220990
- Cited by
- 226
- References
- 2
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- gold
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- Donaldson, K., Brown, D. M., Mitchell, C., Dineva, M., Beswick, P. H., Gilmour, P., & MacNee, W. (1997). Free radical activity of PM10: iron-mediated generation of hydroxyl radicals. Environmental Health Perspectives. https://doi.org/10.1289/ehp.97105s51285
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
