The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin.
Open accessAbstract
Organochlorine compounds, particularly polychlorinated biphenyls (PCBs), alter serum thyroid hormone levels in humans. Hydroxylated organochlorines have relatively high affinities for the serum transport protein transthyretin, but the ability of these compounds to interact with the human thyroid receptor is unknown. Using a baculovirus expression system in insect cells (Sf9 cells), we produced recombinant human thyroid receptor ss (hTRss). In competitive binding experiments, the recombinant receptor had the expected relative affinity for thyroid hormones and their analogs. In competitive inhibition experiments with PCBs, hydroxylated PCBs (OH-PCBs), DDT and its metabolites, and several organochlorine herbicides, only the OH-PCBs competed for binding. The affinity of hTRss for OH-PCBs was 10,000-fold lower (Ki = 20-50 microM) than its affinity for thyroid hormone (3,3',5-triiodothyronine, T3; Ki = 10 nM). Because their relative affinity for the receptor was low, we tested the ability of OH-PCBs to interact with the serum transport proteins--transthyretin and thyroid-binding globulin (TBG). With the exception of one compound, the OH-PCBs had the same affinity (Ki = 10-80 nM) for transthyretin as thyroid hormone (thyroxine; T4). Only two of the OH-PCBs bound TBG (Ki = 3-7 microM), but with a 100-fold lower affinity than T4. Hydroxylated PCBs have relatively low affinities for the human thyroid receptor in vitro, but they have a thyroid hormonelike affinity for the serum transport protein transthyretin. Based on these results, OH-PCBs in vivo are more likely to compete for binding to serum transport proteins than for binding to the thyroid receptor.
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Cites
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Cited by
Polybrominated diphenyl ether (PBDE) flame retardants
Rahman, F., Langford, K. H., Scrimshaw, M. D., & Lester, J. N. (2001) · Science of The Total Environment · doi:10.1016/s0048-9697(01)00852-x · Cited by 656
A perspective on the potential health risks of PBDEs
McDonald, T. A. (2002) · Chemosphere · doi:10.1016/s0045-6535(01)00239-9 · Cited by 648
Environmental Signaling: What Embryos and Evolution Teach Us About Endocrine Disrupting Chemicals
McLachlan, J. A. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.3.0432 · Cited by 608
Self-citationHuman health implications of environmental contaminants in Arctic Canada: a review
Van Oostdam, J., Gilman, A., Dewailly, E., Usher, P., Wheatley, B., Kuhnlein, H., Neve, S., Walker, J., Tracy, B., Feeley, M., et al. (1999) · Science of The Total Environment · doi:10.1016/s0048-9697(99)00036-4 · Cited by 502
Tipping the balance of autism risk: potential mechanisms linking pesticides and autism
Shelton, J. F., Hertz-Picciotto, I., & Pessah, I. N. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104553 · Cited by 164
Metadata
- Authors
- Cheek, A. O., Kow, K., Chen, J., & McLachlan, J. A.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1999-04
- Volume
- 107
- Issue
- 4
- Pages
- 273-278
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2095167055
- Cited by
- 401
- References
- 26
- FWCI
- 18.55
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cheek, A. O., Kow, K., Chen, J., & McLachlan, J. A. (1999). Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. Environmental Health Perspectives. https://doi.org/10.1289/ehp.99107273
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