Serum YKL-40 levels as a novel marker of inflammation in patients with endometriosis
Open accessAbstract
PURPOSE: To establish serum YKL-40 concentrations in patients with endometriosis compared to age-matched healthy subjects. MATERIALS AND METHODS: This was a cross-sectional clinical study conducted in a tertiary care center. Demographics and serum YKL levels were determined and noted in a total of 63 cases (33 endometriosis patients, 30 healthy controls). Measurement of YKL-40 levels was made using a YKL-40 enzyme-linked immunosorbent assay (ELISA) kit according to the manufacturer's protocol. RESULTS: The mean serum YKL-40 levels of the patient group was 106.0 +/- 15.9 (range 23.44 to 382.55) years, while the mean serum YKL-40 levels of the controls was 52.2 +/- 7.0 (range 22.35 to 160.0) years (p = 0.003). CONCLUSIONS: This is the first study evaluating serum YKL-40 levels in endometriosis. The present results indicate that YKL-40 levels were increased in patients with endometriosis compared to controls. The authors propose that circulating YKL-40 levels could be a novel biomarker for diagnosis and follow-up of endometriosis.
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The level of YKL-40 is significantly higher in patients with endometriosis compared with healthy women.
“It was shown that the level of YKL-40 was significantly higher in patients with endometriosis compared with healthy women [150].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [150]
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References 24 · Cited by 12
Research works printed but not linked: 2
- Taylor R.N., Lebovic D.I., Mueller M.D.: "Angiogenic factors in en- dometriosis". Ann. N. Y. Acad. Sci., 2002, 955, 89.
- Kim P.J., Hong D.G., Park J.Y., Cho Y.L., Park I.S., Lee Y.S.: "Im- munohistochemical expression of YKL-40 in peritoneal endometrio- sis". Gynecol. Endocrinol., 2010, 26, 58.
- Authors
- Ural, Ü. M., Tekin, Y. B., Cüre, M. C., & Şahin, F. K. Ş.
- Affiliations
- Recep Tayyip Erdoğan University (TR)
- Corresponding author
- Ural, Ü. Mete
- Venue
- Clinical and Experimental Obstetrics & Gynecology
- Publisher
- IMR Press
- Published
- 2015-08-10
- Volume
- 42
- Issue
- 4
- Pages
- 495-497
- ISSN
- 0390-6663 (ISSN-L)
- OpenAlex
- W2316791087
- Cited by
- 12
- References
- 24
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 1 · 2016: 2
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical and Experimental Obstetrics & Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- YKL-40, endometriosis, serum biomarkers, inflammation, diagnostic biomarkers, disease follow-up
- MeSH terms
- Chitinase-3-Like Protein 1, Adult, Cross-Sectional Studies, Endometriosis, Enzyme-Linked Immunosorbent Assay, Female, Humans, Biomarkers, Case-Control Studies, Lectins, Adipokines
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