Is maternal Vitamin D associated with gestational diabetes mellitus in pregnant women in Cyprus?

Abstract

BACKGROUND: There are conflicting results about the relationship between Vitamin D deficiency (VDD) and gestational diabetes mellitus (GDM). AIM: The aim of the study was to determine the association between 25 hydroxy vitamin D levels and GDM in Turkish Cypriot pregnant women. STUDY DESIGN: The authors conducted a prospective case-control study. MATERIALS AND METHODS: The authors analysed serum 250HD concentrations in 230 pregnant women between 2013-2014 in the winter period (November-April). Twenty- five hydroxy vitamin D was measured at the time of glucose tolerance testing at mid-gestation (24-26 weeks of pregnancy), in a popu- lation at increased risk for GDM. Patients were than divided in to two groups: pregnant women with GDM and pregnant women without GDM. RESULTS: The mean level of 25 hydroxy vitamin D in the study group was 21.9 +10.4 ng/ml. Pregnant women were diagnosed as having vitamin D insufficiency. The level of 25 hydroxy vitamin D in women with and without GDM were 22.3 ± 10.7 ng/dl and 20.3 ± 9.3 ng/dl, respectively (p = 0.262). CONCLUSION: The present study showed 250HD insufficiency in pregnant women at midgestation which was not associated with GDM.