Antihypertensive Effects of Aerobic Exercise in Middle-Aged Normotensive Men with Exaggerated Blood Pressure Response to Exercise.
Open accessAbstract
An exaggerated blood pressure (BP) response to physical exertion among normotensive subjects is considered a significant risk factor for future hypertension. The purpose of this study was to examine whether regular aerobic exercise can lead to a reduction in hypertensive risks in patients with such a high-risk profile. Thirty-five sedentary men (46 +/- 2 years old) with normal BP at rest but an exaggerated BP response during exercise were randomly assigned to an exercise or control group for 12 weeks followed by an 8-week washout period. The subjects were then crossed over to the alternate group for an additional 12-week period. The exercise training consisted of 3 days per week of stationary bicycling for 45 min at 50-60% of the heart rate reserve. The treatment effects were evaluated using the method of Hills and Armitage. The training-induced reduction in resting BP was not statistically significant. In ambulatory BP monitoring, the averages of 24-h and daytime systolic and diastolic BP were significantly lower, but nighttime BP remained unchanged after training. During ergometric exercise, significant decreases were observed in systolic and diastolic BP and plasma norepinephrine concentration measured at the submaximal workloads. M-mode echocardiographic and Doppler-derived left ventricular variables were not significantly affected by training. These findings suggest that regular aerobic exercise attenuates BP elevations during physical exertion and daytime activities mainly as a result of the reduction in enhanced sympathetic nervous tonus, which may in turn play a role in lowering the risk for hypertension in normotensive subjects with an exaggerated BP response to exercise.
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For a given fixed submaximal workload, individuals with greater cardiorespiratory fitness have lower exercise SBP.
“When a workload is fixed at submaximal exercise intensity, individuals with greater cardiorespiratory fitness have lower exercise BP.”
From Cardiorespiratory Fitness, Workload, and the Blood Pressure Response to Exercise Testing (2022) · cites this paper as [55]
The Results report lower systolic and diastolic BP at a submaximal workload after aerobic training, compared with the control period. The paper studied a training effect in sedentary men with exaggerated exercise BP responses; it does not establish that individuals with greater measured cardiorespiratory fitness generally have lower exercise BP. (LLM, conf=0.85)
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References 31 · Cited by 33
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- Authors
- MIYAI, N., ARITA, M., MIYASHITA, K., MORIOKA, I., SHIRAISHI, T., NISHIO, I., & TAKEDA, S.
- Affiliations
- Wakayama Medical University (JP)
- Venue
- Hypertension Research
- Publisher
- Japanese Society of Hypertension
- Published
- 2002
- Volume
- 25
- Issue
- 4
- Pages
- 507-514
- ISSN
- 0916-9636 (ISSN-L)
- OpenAlex
- W2087443072
- Cited by
- 33
- References
- 31
- Citations by year
- 2026: 1 · 2024: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Chiyoda Mutual Life Foundation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- aerobic exercise, blood pressure response to exercise, exaggerated blood pressure response, normotensive men, hypertension risk, stationary cycling, ambulatory blood pressure monitoring, plasma norepinephrine, sympathetic nervous system, left ventricular function, sedentary middle-aged adults
- MeSH terms
- Blood Pressure, Echocardiography, Exercise Test, Humans, Male, Middle Aged, Norepinephrine, Physical Education and Training, Physical Endurance, Reference Values, Exercise, Cross-Over Studies, Echocardiography, Doppler, Pulsed
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