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Cited by 11Cardiovascular Function and Risk FactorsCardiovascular Health and Disease PreventionHeart Failure Treatment and Management

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Hemodynamic characteristics of patients with diastolic heart failure and hypertension.

Open access
FUJIMOTO, Naoki, ONISHI, Katsuya, DOHI, Kaoru, TANABE, Masaki, KURITA, Tairo, TAKAMURA, Takeshi, YAMADA, Norikazu, NOBORI, Tsutomu, ITO, Masaaki·2008·Hypertension Research
DOI 10.1291/hypres.31.1727
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Abstract

Diastolic heart failure (DHF) has different underlying pathophysiologic mechanisms. We sought to compare hemodynamic characteristics in DHF patients with or without hypertension. A conductance catheter with microtip-manometer was used to measure left ventricular (LV) function and hemodynamics in 28 DHF patients. After baseline measurements, nitroglycerin was infused to alter the loading condition and the measurements were repeated. At baseline, end-systolic pressure was higher and the time constant of LV relaxation (tau) was longer in hypertensive DHF patients. Patients in hypertensive DHF had lower LV-arterial coupling ratio than those in non-hypertensive DHF. The peak of loading sequence was in early systole in non-hypertensive DHF patients and in late systole in hypertensive DHF patients. Nitroglycerin decreased LV end-systolic pressure and end-diastolic volume in both groups. In non-hypertensive DHF, nitroglycerin significantly reduced stroke volume and shortened tau (59+/-11 vs. 54+/-10 ms, p<0.05) without any changes in the time to peak LV force, effective arterial elastance (E(a)), or LV-arterial coupling ratio. In contrast, in hypertensive DHF patients, nitroglycerin significantly reduced E(a) and shortened the time to peak LV force, resulting in an improved LV-arterial coupling ratio, preserved stroke volume and shortened tau (75+/-14 vs. 62+/-13 ms, p<0.05). In conclusion, LV relaxation was more prolonged in hypertensive DHF patients than non-hypertensive DHF patients, partly because of the different loading sequence. Changing the loading condition by nitroglycerin improved LV systolic and diastolic function in hypertensive DHF patients.

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Metadata

Authors
FUJIMOTO, N., ONISHI, K., DOHI, K., TANABE, M., KURITA, T., TAKAMURA, T., YAMADA, N., NOBORI, T., & ITO, M.
Affiliations
Mie University (JP)
Corresponding author
ONISHI, Katsuya
ORCID
Venue
Hypertension Research
Publisher
Japanese Society of Hypertension
Published
2008
Volume
31
Issue
9
Pages
1727-1735
ISSN
  • 0916-9636 (ISSN-L)
  • 1348-4214
DOI
10.1291/hypres.31.1727
OpenAlex
W2086449744
Cited by
11
References
27
Citations by year
2026: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1
FWCI
0.24
Type
journal article
Language
en
Open access
Locations
  • Hypertension Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Keywords
heart failure with preserved ejection fraction, hypertension, left ventricular relaxation, effective arterial elastance, nitroglycerin, left ventricular function, hemodynamics, loading sequence, end-systolic pressure, stroke volume
MeSH terms
Aged, Aged, 80 and over, Blood Pressure, Cardiac Volume, Female, Nitroglycerin, Cardiac Catheterization, Humans, Hypertension, Male, Middle Aged, Stroke Volume, Vascular Resistance, Vasodilator Agents, Ventricular Function, Left, Heart Failure, Diastolic

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