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Localized oral histiocytic sarcoma in a leopard gecko (Eublepharis macularius)
Open accessAbstract
A two-year-old female leopard gecko presented with a mass in the oral cavity with apparent exophthalmos. Despite medical management, the animal died. Grossly, the firm and tan to white mass extended from the oropharyngeal region to the external surface overlying the cornea of the left eye. Histologically, the mass was a poorly-demarcated, densely cellular, invasive neoplasm. The neoplasm was composed of solid sheets and interlacing bundles of round, polygonal, and short spindle-shaped cells. Immunohistochemically, the neoplastic cells were positive for Iba-1 and CD204. These findings were consistent with a localized histiocytic sarcoma. This is the first documentation of the gross, histopathological, and immunohistochemical features of localized histiocytic sarcoma in a leopard gecko.
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Cited by 1
Research works printed but not linked: 20
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Metadata
- Authors
- IKEDA, M., KONDO, H., TAKEKUBO, A., TSUNESUMI, N., & SHIBUYA, H.
- Affiliations
- Nihon University (JP)
- small animal clinic, Chiba, Japan
- Corresponding author
- KONDO, Hirotaka
- Venue
- Journal of Veterinary Medical Science
- Published
- 2026
- Volume
- 88
- Issue
- 4
- Pages
- 665-669
- ISSN
- 0916-7250 (ISSN-L)
- 1347-7439
- OpenAlex
- W7131105141
- Cited by
- 1
- References
- 0
- Citations by year
- 2026: 1
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Journal of Veterinary Medical Science (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (JP25KJ2124)
- Topics
- Health Sciences › Veterinary › Small Animals › Veterinary Oncology Research
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Hematology › Histiocytic Disorders and Treatments
- Keywords
- histiocytic sarcoma, leopard gecko, Eublepharis macularius, oral cancer, proptosis, Iba1, CD204, immunohistochemistry, histopathology, reptile neoplasia
- MeSH terms
- Animals, Female, Immunohistochemistry, Lizards, Mouth Neoplasms, Fatal Outcome, Histiocytic Sarcoma
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