Mitochondrial Transmembrane Potential and Reactive Oxygen Species Generation Regulate the Enhanced Effect of CCCP on TRAIL-Induced SNU-638 Cell Apoptosis

CHAUDHARI, Atul A.; SEOL, Jae-Won; KANG, Seog-Jin; PARK, Sang-Youel

doi:10.1292/jvms.70.537

Mitochondrial Transmembrane Potential and Reactive Oxygen Species Generation Regulate the Enhanced Effect of CCCP on TRAIL-Induced SNU-638 Cell Apoptosis

TRAIL is a member of the tumor necrosis factor family and engages apoptosis via recruitment and rapid activation of caspase-8. This study investigated the effect of carbonyl cyanide m-chlorophenylhydrazone (CCCP), a classic uncoupler of oxidative phosphorylation, on TRAIL-induced apoptosis in SNU…