Treadmill exercise alleviates short-term memory impairment in 6-hydroxydopamine-induced Parkinson’s rats
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Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson's disease. In the present study, we investigated the effects of treadmill exercise on short-term memory, apoptotic dopaminergic neuronal cell death and fiber loss in the nigrostriatum, and cell proliferation in the hippocampal dentate gyrus of Parkinson's rats. Parkinson's rats were made by injection of 6-hydroxydopamine (6-OHDA) into the striatum using stereotaxic instrument. Four weeks after 6-OHDA injection, the rats in the 6-OHDA-injection group exhibited significant rotational asymmetry following apomorphine challenge. The rats in the exercise groups were put on the treadmill to run for 30 min once a day for 14 consecutive days starting 4 weeks after 6-OHDA injection. In the present results, extensive degeneration of the dopaminergic neurons in the substantia nigra with loss of dopaminergic fibers in the striatum were produced in the rats without treadmill running, which resulted in short-term memory impairment. However, the rats performing treadmill running for 2 weeks alleviated nigrostriatal dopaminergic cell loss and alleviated short-term memory impairment with increasing cell proliferation in the hippocampal dentate gyrus of Parkinson's rats. The present results show that treadmill exercise may provide therapeutic value for the Parkinson's disease.
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Long-term endurance training increases TH expression in structures involved in extrapyramidal movement regulation, i.e., the ST and midbrain.
“Animal studies have shown that long-term endurance training increased both TrkB receptor and TH expression in structures involved in extrapyramidal movement regulation, i.e., in the ST and midbrain [128,129,179,183,184,185].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [184]
Long-term endurance training increases TrkB receptor expression in structures involved in extrapyramidal movement regulation, i.e., the ST and midbrain.
“Animal studies have shown that long-term endurance training increased both TrkB receptor and TH expression in structures involved in extrapyramidal movement regulation, i.e., in the ST and midbrain [128,129,179,183,184,185].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [184]
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References 33 · Cited by 58
- Authors
- Cho, H.-S., Shin, M.-S., Song, W., Jun, T.-W., Lim, B.-V., Kim, Y.-P., & Kim, C.-J.
- Affiliations
- Seoul National University (KR)
- Dongseo University (KR)
- Jeju National University (KR)
- Kyung Hee University (KR)
- Corresponding author
- Kim, Chang-Ju
- Venue
- Journal of Exercise Rehabilitation
- Published
- 2013-06-30
- Volume
- 9
- Issue
- 3
- Pages
- 354-361
- ISSN
- 2288-176X (ISSN-L)
- 2288-1778
- PMC
- PMC3836534
- OpenAlex
- W1991399534
- Cited by
- 58
- References
- 33
- Citations by year
- 2026: 2 · 2024: 2 · 2022: 1 · 2021: 4 · 2020: 9 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 6
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Exercise Rehabilitation (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- treadmill exercise, Parkinson's disease, short-term memory impairment, 6-hydroxydopamine, dopaminergic neuron loss, substantia nigra, dentate gyrus, cell proliferation, exercise therapy
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