Long-term nicotine replacement therapy
Abstract
The aim of this study is to describe the effectiveness and safety of nicotine replacement therapy (NRT) in 75 pregnant smokers. The cessation rate was 28% after 1 month, and 13% 1 year after delivery. The side-effects of NRT were transitory. Complications to pregnancy were similar in the NRT group and a comparable group. Nicotine replacement products used included either 2mg nicotine gum, or a 15mg nicotine patch (16 hours/day), or both. The individual therapy was decided on the level of nicotine dependence, as measured by the Fagerström score. The concentration of cotinine in saliva and carbon monoxide in expired air was lower when the women used NRT than when they smoked. For women using either nicotine patch or patch plus gum, the mean saliva concentration of cotinine was significantly reduced (p<0.001). For women using only gum, the reduction was borderline significant (p=0.06).
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In one study with very different methods for selecting exposure groups, there was no significant difference in small for gestational age rates.
“The other study used very different methods for selecting exposure groups rendering these non-comparable, but reported no significant difference in SGA rates [54].”
From Fetal safety of nicotine replacement therapy in pregnancy: systematic review and meta-analysis. (2021) · cites this paper as [54]
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References 17 · Cited by 13
- Authors
- Hegaard, H. K., Kjrgaard, H., Mller, L. F., Wachmann, H., & Ottesen, B.
- Affiliations
- Hvidovre Hospital (DK)
- ORCID
- Hegaard, Hanne K
- Venue
- British Journal of Midwifery
- Publisher
- Mark Allen Group
- Published
- 2004-04
- Volume
- 12
- Issue
- 4
- Pages
- 214-220
- ISSN
- 0969-4900 (ISSN-L)
- 2052-4307
- OpenAlex
- W2057137365
- Cited by
- 13
- References
- 17
- Citations by year
- 2026: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2013: 1
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Midwifery (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- nicotine replacement therapy, smoking cessation, pregnancy, nicotine gum, nicotine patch, cotinine, carbon monoxide, nicotine dependence, Fagerström score, adverse effects, maternal smoking
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