A literature review on polynucleotide efficacy on skin rejuvenation, and review of the regulatory status and guidelines around polynucleotides
Abstract
The study on polynucleotide efficacy in skin rejuvenation, alongside the review of regulatory status and guidelines within the UK, delineates a progressive outlook on this emerging therapeutic modality in aesthetic medicine. Polynucleotides have demonstrated notable efficacy in enhancing skin hydration, elasticity, and overall dermal health, primarily through mechanisms that promote cellular repair and collagen synthesis. This systematic review synthesises findings from various clinical studies to elucidate the significant therapeutic potentials of polynucleotides, revealing their capacity to improve skin texture and integrity, which are critical in the aesthetic rejuvenation of aging skin. Further, the review highlights a critical gap in the regulatory framework governing the use of polynucleotides within the United Kingdom.
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Owing to its high water content, PN forms a hydrogel that improves hydration and restores skin viscosity.
“Owing to its high water content, PN forms a hydrogel that improves hydration and restores skin viscosity [31,32,33].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [33]
PN-HA treatments are well-tolerated and effective for repairing the skin barrier.
“PN-HA treatments are well-tolerated and effective for repairing the skin barrier [33,35,41].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [33]
PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes.
“PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes [21,24,31,32,33,34,35,40,41,42,150].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [33]
Cited by
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Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18 · see citing works
- Authors
- Titcomb, L.
- Affiliations
- MSc Cosmetic and Aesthetic Medicine, Faculty of Life Sciences and Education
- Corresponding author
- Titcomb, Lauren
- Venue
- Journal of Aesthetic Nursing
- Publisher
- Mark Allen Group
- Published
- 2025-04-02
- Volume
- 14
- Issue
- 2
- Pages
- 98-126
- ISSN
- 2050-3717 (ISSN-L)
- 2052-2878
- OpenAlex
- W4409359423
- Cited by
- 2
- References
- 0
- Citations by year
- 2025: 2
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Aesthetic Nursing (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- polynucleotides, skin rejuvenation, aesthetic medicine, regulatory framework, skin hydration, skin elasticity, collagen synthesis, cell repair, skin aging, skin texture
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