Chronic Kidney Disease and Coenzyme Q10 Supplementation
Open accessAbstract
Among the potential causes of chronic kidney disease (CKD), mitochondrial respiratory chain (MRC) dysfunction, oxidative stress and inflammation have been implicated as contributor factors to the pathogenesis of this disorder. It is thought that CoQ10 supplementation may offer some therapeutic potential in the treatment of patients with CKD, since CoQ10 has a key role in normal MRC function, as well as having antioxidant and anti-inflammatory action. This article will outline the current knowledge on the use of CoQ10 in the treatment of CKD
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A lack of CoQ10 has been related to several conditions, including aging and neurological disorders.
“A lack of CoQ10 has been related to several conditions, including aging and neurological disorders [83,84,85,86,87,88,89] (Table 1).”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [86]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 86 · Cited by 12
Research works printed but not linked: 30
- Alehagan U, Lindahl TL, Aaseth J, Svensson E, Johansson P. Levels of sP- selectin and hs-CRP decrease with dietary intervention with selenium and CoQ10. PLOS ONE; 10:e0137680, 2015a.
- Alehagan U, Aaseth J, Johansson P. Less increase of copeptin and MR-proADM due to intervention with selenium and CoQ10 for 4 years-follow up results of a randomised controlled trial in elderly citizens. Biofactors; 41: 443-452, 2015b.
- Awad AM, Bradley MC, Fernández-Del-Río L, Nag A, Tsui HS, Clarke CF. CoQ10 deficiencies: pathways in yeast and humans. Essays Biochem; 62: 361-376, 2018.
- Bentinger M, Brismar K, Dallner G. The antioxidant role of CoQ10. Mitochondrion 2007; 7:41-50.
- Bhagavan HN, Chopra RK. Plasma CoQ10 response to oral ingestion of CoQ10 formulations. Mitochondrion 2007;7: 78-88, 2007.
- Cao Q, Li GM, Xu H, et al. CoQ10 treatment for one child with CoQ6 gene mutation induced nephrotic syndrome. Zhonghua Er Ke Za Zhi 2017; 55: 135- 138, 2017.
- Crane FL. Biochemical functions of CoQ10. J Am Coll Nutr. 2000; 20: 591-598.
- Desbats MA, Lunardi G, Doimo M, Trevoisson E, Salviati L. Genetic bases and clinical manifestations of Coq10 deficiency. J Inherit Metab Dis 2015; 38: 145- 156.
- Doimo M, Desbats MA, Cerqua C, Cassina M, Trevisson E, Salviati L. Genetics of CoQ10 deficiency. Mol Syndromol 2014; 5: 156-162.
- Gutierrez-Mariscal FM, Yubero-Serano EM, Villalba JM, Lopez-Miranda J. Coenzyme Q10: from bench to clinic in aging diseases, a translational review. Crit Rev Food Sci Nutr; 16: 1-18, 2018.
- Huang SY, Chen YA, Chen SA, Chen YJ, Lin YK: Uremic toxins-novel arrhythmogenic factors in CKD related atrial fibrillation. Acta Cardiol Sin 2016; 32: 259-264.
- Ishikawa A, Kawarazaki H, Ando K, et al. Renal preservation efect of ubiquinol, the reduced form of CoQ10. Clin Exp Nephrol 2011; 15: 30-33.
- Johansson P, Dahlström Ö, Dahlström U, Alehagen U. Improved health related quality of life and more days out of hospital with supplementation with selenium and CoQ10 combined. J Nutr Health Aging; 19: 870-877, 2015.
- Macunluoglu B, Atakan A, Ari E, et al. Epicardial fat tissue thickness is correlated with diminished levels of CoQ10, a major antioxidant in hemodialysis patients. Clin Biochem 2014; 47: 1231-1234.
- Martinefski M, Samassa P, Buontempo F, Hocht C, Tripodi V. Relative bioavailability of CoQ10 formulation for paediatric individualised therapy. J Pharm Pharmacol 2017; 69: 567-573.
- Mantle D. Coenzyme Q10 and cardiovascular disease: an overview. Brit J Cardiol 2015; 22(4): 1-7.
- Meyer A, Laverny G, Bernardi L, Charles AL, Alsaleh G, Pottecher J et al. Mitochondria: an organelle of bacterial origin controlling inflammation. Front Immunol; 9:536, 2018.
- Montini G, Malaventura C, Salviati L. Early CoQ10 supplementation in primary CoQ10 deficiency. N Enl J Med 2008; 358: 2849-2850.
- Qu H, Guo M, Chai H, Wang W, Gao Z, Shi D. Effects of CoQ10 on statin induced myopathy:an updated meta-analysis of randomised controlled trials. J Am Heart Assoc; 7: e009835, 2018.
- Quinzii C, Naini A, Salviati L, et al. A mutation in para-hydroxybenzoate- polyprenyl transferase causes primary CoQ10 deficiency. Am J Hum Genet 2006; 78: 345-349.
- Schmelzer C, Lindner I, Rimbach G, Menke T, Doring F. Function of coenzyme Q10 in inflammation and gene expression. Biofactors 2008; 32(1-3):179-183.
- Singh RB, Kumar A, Niaz MA, Singh RG, Gujrati S, Singh VP et al. Randomised double blind placebo controlled trial of CoQ10 in chronic renal failure. J Nutr Environ Med 2000; 10: 281-288.
- Skarlovnik A, Janic M, Lunder M, Turk M, Sabovic M. CoQ10 supplementation decreases statin related mild to moderate muscle symptoms: a randomised controlled study. Med Sci Monit; 20: 2183-2188, 2014.
- Su M, Yuan Y, Huang S, et al. Mitochondrial dysfunction is an early event in aldosterone induced podocyte injury. Am J Physiol Renal Physiol 2013; 305: 520-531.
- Triolo L, Lippa S, De Sole P, Mori R. Serum CoQ10 in uremic patients on chronic hemodialysis. Nephron 1994; 66: 153-156.
- Weber C et al.The CoQ10 content of the average Danish diet. Int J Vitam Nutr Res 1997; 67: 123-129.
- Yubero D, Montero R, Artuch R, et al. Biochemical diagnosis of CoQ10 deficiency. Mol Syndromol 2014; 5: 147-155.
- Yubero D, Montero R, Martin MA, et al. Secondary CoQ10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders. Mitochondrion 2016; 30: 51-58.
- Yubero D, Montero R, Santos-Ocana C, Salviati L, Navas P,Artuch R. Molecular diagnosis of Coq10 deficiency: an update. Expert Rev Mol Diagn; 18:491-498, 2018.
- Zahed NS, Ghassami M, Nikbahkt H. Effects of CoQ10 supplementation on C- reactive protein and homocysteine as inflammatory markers in hemodialysis patients: a randomised controlled trial. J Nephropathol 2016; 5: 38-43.
- Authors
- Hargreaves, I., Mantle, D., & Milford, D.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- Medical Adviser, Pharma, Morpeth, Northumberland
- Birmingham Children's Hospital (GB)
- Venue
- Journal of Kidney Care
- Publisher
- Mark Allen Group
- Published
- 2019-03-02
- Volume
- 4
- Issue
- 2
- Pages
- 82-90
- ISSN
- 2397-9534 (ISSN-L)
- 2397-9542
- OpenAlex
- W2923731354
- Cited by
- 12
- References
- 86
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- Locations
- Journal of Kidney Care (publishedVersion)
- Liverpool John Moores University (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- chronic kidney disease, coenzyme Q10, mitochondrial respiratory chain dysfunction, oxidative stress, inflammation, antioxidant activity, anti-inflammatory activity, dietary supplementation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
