The role of neutrophil apoptosis in influencing tissue repair
Abstract
Neutrophils and macrophages are involved in inflammation. Neutrophils debride the area of local contamination and then die (apoptosis) after being engulfed by macrophages. This is vital before the wound can move to the next stage of healing.
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Macrophages remove apoptotic neutrophils, and this phagocytosis may lead to a change toward reparative M2 phenotype and resolution of inflammation.
“Macrophages also remove apoptotic neutrophils, the phagocytosis of which may lead to a change toward a more reparative (M2) macrophage phenotype and the resolution of the inflammatory phase of wound healing [94–96].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [96]
The mechanisms of the M1 to M2 switch during dermal remodeling are not well described but are thought to include phenotypic changes caused by phagocytosis of apoptotic cells and debris by M1 macrophages.
“The mechanisms of this switch from an M1 to an M2 phenotype during dermal remodeling are not well described, but are thought to include phenotypic changes caused by the phagocytosis of apoptotic cells and debris by M1 macrophages [94–96].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [96]
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References 27 · Cited by 62
- Authors
- Sylvia, C. J.
- Affiliations
- Gaymar Industries, Orchard Park, New York, USA
- Corresponding author
- Sylvia, C.J.
- Venue
- Journal of Wound Care
- Publisher
- Mark Allen Group
- Published
- 2003-01
- Volume
- 12
- Issue
- 1
- Pages
- 13-16
- ISSN
- 0969-0700 (ISSN-L)
- 2052-2916
- OpenAlex
- W2095744341
- Cited by
- 62
- References
- 27
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 9 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 5
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Wound Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- neutrophil apoptosis, tissue repair, wound healing, neutrophils, macrophages, inflammation, phagocytosis, wound debridement
- MeSH terms
- Cell Division, Humans, Inflammation, Macrophages, Neutrophils, Wound Healing, Cytokines, Apoptosis, Tissue Engineering
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