Probiotic mixture VSL# 3: An overview of basic and clinical studies in chronic diseases
Open accessAbstract
Probiotics are known as "live microorganisms" and have been proven to have a health effect on hosts at the proper dose. Recently, a kind of probiotic mixture including eight live bacterial strains, VSL#3, has attracted considerable attention for its combined effect. VSL#3 is the only probiotic considered as a kind of medical food; it mainly participates in the regulation of the intestinal barrier function, including improving tight junction protein function, balancing intestinal microbial composition, regulating immune-related cytokine expression and so on. The objective of this review is to discuss the treatment action and mechanism for the administration of VSL#3 in chronic diseases of animals and humans (including children). We found that VSL#3 has a therapeutic or preventive effect in various systemic diseases per a large number of studies, including digestive systemic diseases (gastrointestinal diseases and hepatic diseases), obesity and diabetes, allergic diseases, nervous systemic diseases, atherosclerosis, bone diseases, and female reproductive systemic diseases.
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Probiotics interact with intestinal bacteria after entering the intestine, enhancing the chemical barrier, biological barrier, immune barrier, and mechanical barrier.
“After that, probiotics react with bacteria following their entrance into the intestine, enhancing the chemical barrier, biological barrier, immune barrier, and mechanical barrier [84].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [84]
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References 169 · Cited by 147
- Authors
- Cheng, F.-S., Pan, D., Chang, B., Jiang, M., & Sang, L.-X.
- Affiliations
- Sheng Jing Hospital (CN)
- First Hospital of China Medical University (CN)
- Venue
- World Journal of Clinical Cases
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2020-04-26
- Volume
- 8
- Issue
- 8
- Pages
- 1361-1384
- ISSN
- 2307-8960 (ISSN-L)
- PMC
- PMC7190945
- OpenAlex
- W3019535980
- Cited by
- 147
- References
- 169
- Citations by year
- 2026: 20 · 2025: 29 · 2024: 26 · 2023: 25 · 2022: 31 · 2021: 11 · 2020: 5
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- World Journal of Clinical Cases (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- VSL#3, probiotics, medical foods, intestinal barrier function, tight junction proteins, gut microbiota, chronic disease, gastrointestinal diseases, liver disease, obesity, diabetes mellitus, allergic diseases, neurological disorders, atherosclerosis, bone disease, gynecological diseases, children
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