Remimazolam benzenesulfonate anesthesia effectiveness in cardiac surgery patients under general anesthesia
Open accessAbstract
BACKGROUND: Sedation with propofol injections is associated with a risk of addiction, but remimazolam benzenesulfonate is a comparable anesthetic with a short elimination half-life and independence from cell P450 enzyme metabolism. Compared to remimazolam, remimazolam benzenesulfonate has a faster effect, is more quickly metabolized, produces inactive metabolites and has weak drug interactions. Thus, remimazolam benzenesulfonate has good effectiveness and safety for diagnostic and operational sedation. AIM: To investigate the clinical value of remimazolam benzenesulfonate in cardiac surgery patients under general anesthesia. METHODS: A total of 80 patients who underwent surgery in the Department of Cardiothoracic Surgery from August 2020 to April 2021 were included in the study. Using a random number table, patients were divided into two anesthesia induction groups of 40 patients each: remimazolam (0.3 mg/kg remimazolam benzenesulfonate) and propofol (1.5 mg/kg propofol). Hemodynamic parameters, inflammatory stress response indices, respiratory function indices, perioperative indices and adverse reactions in the two groups were monitored over time for comparison. RESULTS: < 0.05). CONCLUSION: Compared with propofol, remimazolam benzenesulfonate benefited cardiac surgery patients under general anesthesia by reducing hemodynamic fluctuations. Remimazolam benzenesulfonate influenced the surgical stress response and respiratory function, thereby reducing anesthesia-related adverse reactions.
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There was no statistically significant difference in prevalence of nausea and vomiting between remimazolam and propofol (OR = 1.32; 95% CI, 0.73 to 2.39; I2 = 33%).
“Based on the fixed-effects model, the OR of remimazolam to propofol in the subgroup of nausea and vomiting was 1.32 95% CI, 0.73 to 2.39; I² = 33%) (Fig. 12), indicating that there existed no statistical conspicuous discrepancy in the prevalence of nausea and vomiting between the 2 arms.”
From Hemodynamic Influences of Remimazolam Versus Propofol During the Induction Period of General Anesthesia: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2023) · cites this paper as [18]
The Results section, Table 6 (page not provided), reports nausea in 1 of 40 remimazolam patients versus 3 of 40 propofol patients, and emesis in 0 versus 1. It does not report a statistical test specifically for nausea and vomiting, or the claimed pooled OR, confidence interval, and I². Its significant P value concerns all adverse reactions combined. (LLM, conf=0.87)
Experimental — accuracy not yet measuredFive of the included trials were regarded as high-quality.
“Among these trials, 5 were regarded high-quality (18-22) (Figs. 2, 3).”
Risk of bias was high in 2 trials and moderate in 2 trials for blinding of patients and personnel.
“The risk of bias was rated as high in 2 trials and moderate in 2 trials for the domain of patients and personnel blinding (15-18).”
No meaningful change in nausea/vomiting results was obtained with sensitivity analysis and random-effects model.
“No meaningful change in the results was obtained when the sensitivity analysis and the random-effects model were used (15,17,18,20,22).”
From Hemodynamic Influences of Remimazolam Versus Propofol During the Induction Period of General Anesthesia: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2023) · cites this paper as [18]
The Statistical analyses section describes t-tests and χ² tests, but does not report a sensitivity analysis or a random-effects model. The Results section tabulates nausea and emesis as adverse reactions, without saying whether either analysis changed those results (searched: sensitivity analysis, random-effects model, nausea/vomiting). (LLM, conf=0.77)
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- Authors
- Tang, F., Yi, J.-M., Gong, H.-Y., Lu, Z.-Y., Chen, J., Fang, B., Chen, C., & Liu, Z.-Y.
- Affiliations
- First Affiliated Hospital of Nanchang University (CN)
- ORCID
- Chen, Jie
- Venue
- World Journal of Clinical Cases
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2021-12-06
- Volume
- 9
- Issue
- 34
- Pages
- 10595-10603
- ISSN
- 2307-8960 (ISSN-L)
- PMC
- PMC8686148
- OpenAlex
- W3216309176
- Cited by
- 76
- References
- 20
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 22 · 2023: 21 · 2022: 8
- FWCI
- 14.63
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Clinical Cases (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- remimazolam, propofol, general anesthesia, cardiac surgery, anesthesia induction, hemodynamic stability, inflammatory stress response, respiratory function, anesthetic side effects
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