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Antibiotic-loaded acrylic cement
Abstract
Laboratory experiments and clinical investigations have confirmed the various claims made originally by Buchholz and Engelbrecht (1970) that antibiotic-loaded acrylic cement releases the antibiotic into the surroundings in useful concentrations. Palacos R cement released higher concentrations than CMW, Simplex and Sulfix brands of cement and over longer periods. Concentrations of gentamycin and fucidin were sufficient to penetrate dead cortical bone. These conclusions need to be assessed with animal studies, mechanical testing and clinical results before the ideal place of antibiotic-loaded acrylic cement is established.
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Citations
Cited by
Infection after total hip arthroplasty. Past, present, and future.
Garvin, K. L., & Hanssen, A. D. (1995) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-199510000-00015 · Cited by 497
Long-term elution of antibiotics from bone-cement
Masri, B. A., Duncan, C. P., & Beauchamp, C. P. (1998) · The Journal of Arthroplasty · doi:10.1016/s0883-5403(98)90179-6 · Cited by 356
Elution characteristics of vancomycin and tobramycin combined in acrylic bone—cement
Penner, M. J., Masri, B. A., & Duncan, C. P. (1996) · The Journal of Arthroplasty · doi:10.1016/s0883-5403(96)80135-5 · Cited by 324
van de Belt, H., Neut, D., Uges, D. R. A., Schenk, W., van Horn, J. R., van der Mei, H. C., & Busscher, H. J. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00082-x · Cited by 277
Release of gentamicin from acrylic bone cement
Bunetel, L., Segui, A., Cormier, M., Percheron, E., & Langlais, F. (1989) · Clinical Pharmacokinetics · doi:10.2165/00003088-198917040-00006 · Cited by 123
Metadata
- Authors
- Elson, R., Jephcott, A., McGechie, D., & Verettas, D.
- Venue
- The Journal of Bone and Joint Surgery. British volume
- Published
- 1977-05
- Volume
- 59-B
- Issue
- 2
- Pages
- 200-205
- ISSN
- 0301-620X (ISSN-L)
- 2044-5377
- OpenAlex
- W2267092934
- Cited by
- 179
- References
- 0
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Antibiotic-loaded acrylic cement. https://app.cochat.ai/papers/10.1302/0301-620x.59b2.873980
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- Elson, R., Jephcott, A., McGechie, D., & Verettas, D. (1977). Antibiotic-loaded acrylic cement. The Journal of Bone and Joint Surgery. British volume. https://doi.org/10.1302/0301-620x.59b2.873980
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
