The DOI matches its OpenAlex record.
Chondrocyte Transplantation Using a Collagen Bilayer Matric for Cartilage Repair
Abstract
We have developed a novel, two-layered, collagen matrix seeded with chondrocytes for repair of articular cartilage. It consists of a dense collagen layer which is in contact with bone and a porous matrix to support the seeded chondrocytes. The matrices were implanted in rabbit femoral trochleas for up to 24 weeks. The control groups received either a matrix without cells or no implant. The best histological repair was seen with cell-seeded implants. The permeability and glycosaminoglycan content of both implant groups were nearly normal, but were significantly less in tissue from empty defects. The type-II collagen content of the seeded implants was normal. For unseeded implants it was 74.3% of the normal and for empty defects only 20%. The current treatments for articular injury often result in a fibrous repair which deteriorates with time. This bilayer implant allowed sustained hyaline-like repair of articular defects during the entire six-month period of observation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Collagens—structure, function, and biosynthesis
Gelse, K. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.08.002 · Cited by 2,654
HORAS, U., PELINKOVIC, D., HERR, G., AIGNER, T., & SCHNETTLER, R. (2003) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200302000-00001 · Cited by 784
Current Concepts Review - The Healing and Regeneration of Articular Cartilage*
OʼDRISCOLL, S. W. (1998) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-199812000-00011 · Cited by 629
A critical review on polymer-based bio-engineered materials for scaffold development
Cheung, H.-Y., Lau, K.-T., Lu, T.-P., & Hui, D. (2007) · Composites Part B: Engineering · doi:10.1016/j.compositesb.2006.06.014 · Cited by 531
Sechriest, V. F., Miao, Y. J., Niyibizi, C., Westerhausen–Larson, A., Matthew, H. W., Evans, C. H., Fu, F. H., & Suh, J. (2000) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(20000315)49:4<534::aid-jbm12>3.0.co;2-# · Cited by 305
Metadata
- Authors
- Frenkel, S. R., Toolan, B. C., Menche, D. S., Pitman, M. I., & Pachence, J. M.
- Venue
- Journal of Bone and Joint Surgery - British Volume
- Publisher
- British Editorial Society of Bone & Joint Surgery
- Published
- 1997-09-01
- Volume
- 79
- Issue
- 5
- Pages
- 831-836
- ISSN
- 0301-620X (ISSN-L)
- OpenAlex
- W2143835908
- Cited by
- 228
- References
- 0
- FWCI
- 7.30
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Chondrocyte Transplantation Using a Collagen Bilayer Matric for Cartilage Repair. https://app.cochat.ai/papers/10.1302/0301-620x.79b5.7278
- The paper
- Frenkel, S. R., Toolan, B. C., Menche, D. S., Pitman, M. I., & Pachence, J. M. (1997). Chondrocyte Transplantation Using a Collagen Bilayer Matric for Cartilage Repair. Journal of Bone and Joint Surgery - British Volume. https://doi.org/10.1302/0301-620x.79b5.7278
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
