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Nonunion of the femoral diaphysis: THE INFLUENCE OF REAMING AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
Abstract
We assessed factors which may affect union in 32 patients with nonunion of a fracture of the diaphysis of the femur and 67 comparable patients whose fracture had united. These included gender, age, smoking habit, the use of non-steroidal anti-inflammatory drugs (NSAIDs) the type of fracture (AO classification), soft-tissue injury (open or closed), the type of nail, the mode of locking, reaming v non-reaming, infection, failure of the implant, distraction at the fracture site, and the time to full weight-bearing. Patients with severe head injuries were excluded. Both groups were comparable with regard to gender, Injury Severity Score and soft-tissue injury. There was no relationship between the rate of union and the type of implant, mode of locking, reaming, distraction or smoking. There were fewer cases of nonunion in more comminuted fractures (type C) and in patients who were able to bear weight early. There was a marked association between nonunion and the use of NSAIDs after injury (p = 0.000001) and delayed healing was noted in patients who took NSAIDs and whose fractures had united.
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Citations
Cited by
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Spicer, P. P., Kretlow, J. D., Young, S., Jansen, J. A., Kasper, F. K., & Mikos, A. G. (2012) · Nature Protocols · doi:10.1038/nprot.2012.113 · Cited by 664
Cellular biology of fracture healing
Bahney, C. S., Zondervan, R. L., Allison, P., Theologis, A., Ashley, J. W., Ahn, J., Miclau, T., Marcucio, R. S., & Hankenson, K. D. (2019) · Journal of Orthopaedic Research · doi:10.1002/jor.24170 · Cited by 577
Cigarette Smoking Increases Complications Following Fracture: A Systematic Review
Scolaro, J. A., Schenker, M. L., Yannascoli, S., Baldwin, K., Mehta, S., & Ahn, J. (2014) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.m.00081 · Cited by 279
The influence of osteoporosis in femoral fracture healing time
Nikolaou, V. S., Efstathopoulos, N., Kontakis, G., Kanakaris, N. K., & Giannoudis, P. V. (2009) · Injury · doi:10.1016/j.injury.2008.10.035 · Cited by 185
Pearson, R. G., Clement, R. G. E., Edwards, K. L., & Scammell, B. E. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010303 · Cited by 174
Metadata
- Authors
- Giannoudis, P. V., MacDonald, D. A., Matthews, S. J., Smith, R. M., Furlong, A. J., & De Boer, P.
- Venue
- The Journal of Bone and Joint Surgery. British volume
- Published
- 2000-07
- Volume
- 82-B
- Issue
- 5
- Pages
- 655-658
- ISSN
- 0301-620X (ISSN-L)
- 2044-5377
- OpenAlex
- W2988816971
- Cited by
- 411
- References
- 0
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Nonunion of the femoral diaphysis: THE INFLUENCE OF REAMING AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS. https://app.cochat.ai/papers/10.1302/0301-620x.82b5.0820655
- The paper
- Giannoudis, P. V., MacDonald, D. A., Matthews, S. J., Smith, R. M., Furlong, A. J., & De Boer, P. (2000). Nonunion of the femoral diaphysis: THE INFLUENCE OF REAMING AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS. The Journal of Bone and Joint Surgery. British volume. https://doi.org/10.1302/0301-620x.82b5.0820655
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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