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Repair of cartilage defect in the rabbit with cultured mesenchymal stem cells from bone marrow
Abstract
In 16 mature New Zealand white rabbits mesenchymal stem cells were aspirated from the bone marrow, cultured in monolayer and implanted on to a full-thickness osteochondral defect artificially made on the patellar groove of the same rabbit. A further 13 rabbits served as a control group. The rabbits were killed after 14 weeks. Healing of the defect was investigated histologically using haematoxylin and eosin and Safranin-O staining and with immunohistochemical staining for type-II collagen. We also used a reverse transcription-polymerase chain reaction (RT-PCR) to detect mRNA of type-I and type-II collagen. The semiquantitative histological scores were significantly higher in the experimental group than in the control group (p < 0.05). In the experimental group immunohistochemical staining on newly formed cartilage was more intense for type-II collagen in the matrix and RT-PCR from regenerated cartilage detected mRNA for type-II collagen in mature chondrocytes. These findings suggest that repair of cartilage defects can be enhanced by the implantation of cultured mesenchymal stem cells.
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Cited by
Adipose-derived adult stromal cells heal critical-size mouse calvarial defects
Cowan, C. M., Shi, Y.-Y., Aalami, O. O., Chou, Y.-F., Mari, C., Thomas, R., Quarto, N., Contag, C. H., Wu, B., & Longaker, M. T. (2004) · Nature Biotechnology · doi:10.1038/nbt958 · Cited by 914
Sakai, D., Mochida, J., Yamamoto, Y., Nomura, T., Okuma, M., Nishimura, K., Nakai, T., Ando, K., & Hotta, T. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00222-9 · Cited by 406
Stem cell homing in musculoskeletal injury
Fong, E. L. S., Chan, C. K., & Goodman, S. B. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.101 · Cited by 212
Boyette, L. B., Creasey, O. A., Guzik, L., Lozito, T., & Tuan, R. S. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0079 · Cited by 121
The role of bone marrow derived mesenchymal stem cells in sports injuries
Vris, A., Aresti, N., Khan, W. S., & Malik, A. A. (2016) · Stem Cells in Clinical Applications · doi:10.1007/978-3-319-40144-7_14 · Cited by 28
Metadata
- Authors
- Im, G.-I., Kim, D.-Y., Shin, J.-H., Hyun, C.-W., & Cho, W.-H.
- Venue
- The Journal of Bone and Joint Surgery. British volume
- Published
- 2001-03
- Volume
- 83-B
- Issue
- 2
- Pages
- 289-294
- ISSN
- 0301-620X (ISSN-L)
- 2044-5377
- OpenAlex
- W1967474304
- Cited by
- 233
- References
- 0
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Im, G.-I., Kim, D.-Y., Shin, J.-H., Hyun, C.-W., & Cho, W.-H. (2001). Repair of cartilage defect in the rabbit with cultured mesenchymal stem cells from bone marrow. The Journal of Bone and Joint Surgery. British volume. https://doi.org/10.1302/0301-620x.83b2.0830289
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
