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Breast cancer liver metastases: systematic review and time to event meta-analysis with comparison between available treatments
Open accessAbstract
Introduction: The current gold standard treatment for breast cancer liver metastases (BCLM) is systemic chemotherapy and/or hormonal therapy. Nonetheless, greater consideration has been given to local therapeutic strategies in recent years. We sought to compare survival outcomes for available systemic and local treatments for BCLM, specifically surgical resection and radiofrequency ablation. Methods: A review of the PubMed (MEDLINE), Embase and Cochrane Library databases was conducted. Data from included studies were extracted and subjected to time-to-event data synthesis, algorithmically reconstructing individual patient-level data from published Kaplan–Meier survival curves. Findings: A total of 54 studies were included, comprising data for 5,430 patients (surgery, n=2,063; ablation, n=305; chemotherapy, n=3,062). Analysis of the reconstructed data demonstrated survival rates at 1, 3 and 5 years of 90%, 65.9% and 53%, respectively, for the surgical group, 83%, 49% and 35% for the ablation group and 53%, 24% and 14% for the chemotherapy group (p<0.0001). Conclusion: Local therapeutic interventions such as liver resection and radiofrequency ablation are effective treatments for BCLM, particularly in patients with metastatic disease localised to the liver. Although the data from this review support surgical resection for BCLM, further prospective studies for managing oligometastatic breast cancer disease are required.
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“when complete resection is feasible, surgical resection may provide more favorable long-term outcomes.18)”
From Liver Resection after Disease Control with Abemaciclib for Solitary Liver Metastasis from Breast Cancer: A Case Report (2026) · cites this paper as [18]
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“18) In this case, if RFA had been selected, the tumor location adjacent to the right hepatic vein may have reduced the efficacy of thermal ablation due to the heat sink effect, 19) and tumors near major vessels are associated with higher local recurrence rates.”
Metadata
- Authors
- Rangarajan, K., Lazzereschi, L., Votano, D., & Hamady, Z.
- Affiliations
- University Hospital Southampton NHS Foundation Trust (GB)
- Ashford and St Peter's Hospitals NHS Foundation Trust (GB)
- Venue
- The Annals of The Royal College of Surgeons of England
- Publisher
- Royal College of Surgeons of England
- Published
- 2023-04
- Volume
- 105
- Issue
- 4
- Pages
- 293-305
- ISSN
- 0035-8843 (ISSN-L)
- 1478-7083
- PMC
- PMC10066639
- OpenAlex
- W4213266198
- Semantic Scholar
- 0c3a2c952706e20caeeaa230851602ae8a41e678
- Cited by
- 16
- References
- 69
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 3 · 2023: 1
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of The Royal College of Surgeons of England (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Keywords
- breast cancer liver metastasis, hepatectomy, radiofrequency ablation, systemic chemotherapy, hormone therapy, survival outcomes, local therapy, oligometastatic disease
- MeSH terms
- Melanoma, Cutaneous Malignant, Cutaneous Malignant Melanoma, Breast Neoplasms, Female, Hepatectomy, Humans, Liver Neoplasms, Prospective Studies, Treatment Outcome
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