Osteosarcoma: Anatomic and Histologic Variants
Abstract
Osteosarcoma is the most common primary tumor of bone, yet its absolute incidence among malignant tumors is low. Within its strict histologic definition, osteosarcoma comprises a family of lesions with considerable diversity in histologic features and grade. Its prognosis is dependent not only on these parameters but also on its anatomic site. It may occur inside the bones (in the intramedullary or intracortical compartment), on the surfaces of bones, and in extraosseous sites. Information of diagnostic or prognostic significance has not been elucidated from studies of its cytogenetics. This review summarizes the anatomic and histologic variations of osteosarcoma and offers a schema for its subclassification.
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Osteosarcoma is histologically defined as a tumour of osteoid-producing cells that often exist within an admixture of adipogenic, muscle, spindle, fibroblastic and chondroblastic cells.
“Osteosarcoma is defined histologically as a tumour of osteoid-producing cells, which often exist within an admixture of adipogenic, muscle, spindle, fibroblastic and chondroblastic cells 3 .”
From Osteosarcoma (2022) · cites this paper as [3]
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References 36 · Cited by 386
- Authors
- Klein, M. J., & Siegal, G. P.
- Affiliations
- University of Alabama at Birmingham (US)
- Venue
- American Journal of Clinical Pathology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-04
- Volume
- 125
- Issue
- 4
- Pages
- 555-581
- ISSN
- 0002-9173 (ISSN-L)
- 1943-7722
- OpenAlex
- W4236150506
- Cited by
- 386
- References
- 36
- Citations by year
- 2026: 13 · 2025: 24 · 2024: 27 · 2023: 14 · 2022: 23 · 2021: 34 · 2020: 23 · 2019: 28 · 2018: 11 · 2017: 18 · 2016: 24 · 2015: 23 · 2014: 39 · 2013: 18 · 2012: 16
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Pathology (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
- Keywords
- osteosarcoma, primary bone tumors, histological classification, tumor grade, prognosis, anatomical site, extraosseous osteosarcoma, cytogenetics, subclassification
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