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Host-Dependent Patterns of Tissue Injury in Invasive Pulmonary Aspergillosis
Open accessAbstract
Invasive pulmonary aspergillosis (IPA) is an important cause of morbidity and mortality in neutropenic, nonneutropenic, and other immunocompromised patients. We therefore compared the patterns of infection and inflammation among 3 cohorts of immunocompromised patients with profound neutropenia, nonneutropenic immunosuppression, and hematopoietic stem cell transplantation. Lesions of IPA in neutropenic patients and hematopoietic stem cell transplant (HSCT) recipients were similar and consisted predominantly of angioinvasion and intraalveolar hemorrhage. The frequency of these histologic findings in neutropenic patients and HSCT recipients differed significantly from those of nonneutropenic patients (P < .05). It is noteworthy that even if HSCT recipients have normal peripheral blood neutrophil counts, there may be no influx into sites of infection. In the nonneutropenic cohort, lesions of IPA consisted mainly of neutrophilic and monocytic infiltrates and inflammatory necrosis. Thus, the status of innate host defenses contributes significantly to the histologic patterns observed in IPA.
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The nonangioinvasive form of IPA has been increasingly recognized in a wide range of nonneutropenic hosts.
“The nonangioinvasive form of IPA has been increasingly recognized in a wide range of nonneutropenic hosts (89, 90).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [90]
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References 28 · Cited by 152
Research works printed but not linked: 1
- Denning DW. Invasive aspergillosis. Clin Infect Dis. 1998; 26:781-805.
Metadata
- Authors
- Stergiopoulou, T., Meletiadis, J., Roilides, E., Kleiner, D. E., Schaufele, R., Roden, M., Harrington, S., Dad, L., Segal, B., & Walsh, T. J.
- Affiliations
- National Institutes of Health (US)
- Roswell Park Comprehensive Cancer Center (US)
- ORCID
- Venue
- American Journal of Clinical Pathology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-03
- Volume
- 127
- Issue
- 3
- Pages
- 349-355
- ISSN
- 0002-9173 (ISSN-L)
- 1943-7722
- OpenAlex
- W2127478210
- Cited by
- 152
- References
- 28
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 3 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 11 · 2018: 6 · 2017: 10 · 2016: 3 · 2015: 2 · 2014: 12 · 2013: 5 · 2012: 4
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Clinical Pathology (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Funders
- National Institutes of Health
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- invasive pulmonary aspergillosis, vascular invasion, neutropenia, hematopoietic stem cell transplantation, innate host defense, neutrophil infiltration, immunocompromised patients
- MeSH terms
- Adolescent, Adult, Aged, Aspergillosis, Aspergillus, Aspergillus fumigatus, Blood Vessels, Child, Child, Preschool, Female, Hemorrhage, Humans, Lung Diseases, Fungal, Male, Middle Aged, Neutropenia, Cohort Studies, Immunocompromised Host, Hematopoietic Stem Cell Transplantation
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